Bibliographic Details
| Title: |
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1 |
| Authors: |
Wenfeng He, Hongtao Chang, Chen Li, Chenlong Wang, Longxi Li, Guoqing Yang, Jing Chen, Huimin Liu |
| Source: |
Virology Journal, Vol 21, Iss 1, Pp 1-17 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
STRAP, TBK1, Pseudorabies virus, Antiviral immunity, Type I interferon, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Abstract Serine/threonine kinase receptor-associated protein (STRAP) serves as a scaffold protein and is engaged in a variety of cellular activities, although its importance in antiviral innate immunity is unknown. We discovered that STRAP works as an interferon (IFN)-inducible positive regulator, facilitating type I IFN signaling during pseudorabies virus infection. Mechanistically, STRAP interacts with TBK1 to activate type I IFN signaling. Both the CT and WD40 7 − 6 domains contribute to the function of STRAP. Furthermore, TBK1 competes with PRV-UL50 for binding to STRAP, and STRAP impedes the degradation of TBK1 mediated by PRV-UL50, thereby increasing the interaction between STRAP and TBK1. Overall, these findings reveal a previously unrecognized role for STRAP in innate antiviral immune responses during PRV infection. STRAP could be a potential therapeutic target for viral infectious diseases. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1743-422X |
| Relation: |
https://doaj.org/toc/1743-422X |
| DOI: |
10.1186/s12985-024-02474-z |
| Access URL: |
https://doaj.org/article/0c9f80c5a4bf4a5fbf61616e629fd137 |
| Accession Number: |
edsdoj.0c9f80c5a4bf4a5fbf61616e629fd137 |
| Database: |
Directory of Open Access Journals |
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