Assessing the efficiency of eligibility criteria for low-dose computed tomography lung screening in China according to current guidelines

Bibliographic Details
Title: Assessing the efficiency of eligibility criteria for low-dose computed tomography lung screening in China according to current guidelines
Authors: Yanyan Tang, Lina Zhou, Fei Wang, Yao Huang, Jianwei Wang, Shijun Zhao, Linlin Qi, Li Liu, Min Liang, Donghui Hou, Zhijian Xu, Kai Zhang, Wei Tang, Ning Wu
Source: BMC Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Publisher Information: BMC, 2024.
Publication Year: 2024
Collection: LCC:Medicine
Subject Terms: Lung cancer screening, LDCT, Guideline, Eligibility criteria, Efficiency, Medicine
More Details: Abstract Background Evidence from observational studies indicates that lung cancer screening (LCS) guidelines with high rates of lung cancer (LC) underdiagnosis, and although current screening guidelines have been updated and eligibility criteria for screening have been expanded, there are no studies comparing the efficiency of LCS guidelines in Chinese population. Methods Between 2005 and 2022, 31,394 asymptomatic individuals were screened using low-dose computed tomography (LDCT) at our institution. Demographic data and relevant LC risk factors were collected. The efficiency of the LCS for each guideline criteria was expressed as the efficiency ratio (ER). The inclusion rates, eligibility rates, LC detection rates, and ER based on the different eligibility criteria of the four guidelines were comparatively analyzed. The four guidelines were as follows: China guideline for the screening and early detection of lung cancer (CGSL), the National Comprehensive Cancer Network (NCCN), the United States Preventive Services Task Force (USPSTF), and International Early Lung Cancer Action Program (I-ELCAP). Results Of 31,394 participants, 298 (155 women, 143 men) were diagnosed with LC. For CGSL, NCCN, USPSTF, and I-ELCAP guidelines, the eligibility rates for guidelines were 13.92%, 6.97%, 6.81%, and 53.46%; ERe for eligibility criteria were 1.46%, 1.64%, 1.51%, and 1.13%, respectively; and for the inclusion rates, they were 19.0%, 9.5%, 9.3%, and 73.0%, respectively. LCs which met the screening criteria of CGSL, NCCN, USPSTF, and I-ELCAP guidelines were 29.2%, 16.4%, 14.8%, and 86.6%, respectively. The age and smoking criteria for CGSL were stricter, hence resulting in lower rates of LC meeting the screening criteria. The CGSL, NCCN, and USPSTF guidelines showed the highest underdiagnosis in the 45–49 age group (17.4%), while the I-ELCAP guideline displayed the highest missed diagnosis rate (3.0%) in the 35–39 age group. Males and females significantly differed in eligibility based on the criteria of the four guidelines (P
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1741-7015
Relation: https://doaj.org/toc/1741-7015
DOI: 10.1186/s12916-024-03445-5
Access URL: https://doaj.org/article/0c929750b20a487d9435362cc5395bab
Accession Number: edsdoj.0c929750b20a487d9435362cc5395bab
Database: Directory of Open Access Journals
Full text is not displayed to guests.
More Details
ISSN:17417015
DOI:10.1186/s12916-024-03445-5
Published in:BMC Medicine
Language:English