Bibliographic Details
| Title: |
Associations of plasma SMOC1 and soluble IL6RA levels with the progression from mild cognitive impairment to dementia |
| Authors: |
Xavier Morató, Raquel Puerta, Amanda Cano, Adelina Orellana, Itziar de Rojas, María Capdevila, Laura Montrreal, Maitée Rosende-Roca, Pablo García-González, Claudia Olivé, Fernando García-Gutiérrez, Josep Blázquez, Andrea Miguel, Raúl Núñez-Llaves, Vanesa Pytel, Montserrat Alegret, María Victoria Fernández, Marta Marquié, Sergi Valero, Jose Enrique Cavazos, Santos Mañes, Mercè Boada, Alfredo Cabrera-Socorro, Agustín Ruiz |
| Source: |
Brain, Behavior, & Immunity - Health, Vol 42, Iss , Pp 100899- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
sIL6RA, SMOC1, Alzheimer's disease, Inflammation, Mild cognitive impairment, Disease progression, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Despite the central role attributed to neuroinflammation in the etiology and pathobiology of Alzheimer's disease (AD), the direct link between levels of inflammatory mediators in blood and cerebrospinal fluid (CSF) compartments, as well as their potential implications for AD diagnosis and progression, remains inconclusive. Moreover, there is debate on whether inflammation has a protective or detrimental effect on disease onset and progression. Indeed, distinct immunological mechanisms may govern protective and damaging effects at early and late stages, respectively.This study aims to (i) identify inflammatory mediators demonstrating robust correlations between peripheral and central nervous system (CNS) compartments by means of plasma and CSF analysis, respectively, and (ii) assess their potential significance in the context of AD and disease progression from mild cognitive impairment (MCI) to dementia. To achieve this, we have examined the inflammatory profile of a well-defined subcohort comprising 485 individuals from the Ace Alzheimer Center Barcelona (ACE). Employing a hierarchical clustering approach, we thoroughly evaluated the intercompartmental correlations of 63 distinct inflammation mediators, quantified in paired CSF and plasma samples, using advanced SOMAscan technology. Of the array of mediators investigated, only six mediators (CRP, IL1RAP, ILRL1, IL6RA, PDGFRB, and YKL-40) exhibited robust correlations between the central and peripheral compartments (proximity scores 1.3, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2666-3546 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2666354624001777; https://doaj.org/toc/2666-3546 |
| DOI: |
10.1016/j.bbih.2024.100899 |
| Access URL: |
https://doaj.org/article/cec0c618b8b14d4db849327800647c8b |
| Accession Number: |
edsdoj.0c618b8b14d4db849327800647c8b |
| Database: |
Directory of Open Access Journals |
