Academic Journal
The Diagnostic Potential of Non-Invasive Tools for Oral Cancer and Precancer: A Systematic Review
| Title: | The Diagnostic Potential of Non-Invasive Tools for Oral Cancer and Precancer: A Systematic Review |
|---|---|
| Authors: | Tania Vanessa Pierfelice, Emira D’Amico, Chiara Cinquini, Giovanna Iezzi, Camillo D’Arcangelo, Simonetta D’Ercole, Morena Petrini |
| Source: | Diagnostics, Vol 14, Iss 18, p 2033 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine (General) |
| Subject Terms: | non-invasive diagnostic tools, oral cancer, oral precancer, vital staining, oral brush, light-based technology, Medicine (General), R5-920 |
| More Details: | Objectives: This systematic review aimed to analyse the published evidence for the use of non-invasive methods for the early detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). Methods: The literature was systematically searched through several databases: PubMed, Cochrane Library, and Web of Science. Additional exploration was performed through cross-checks on the bibliographies of selected reviews. The inclusion criteria involved studies assessing the application of non-invasive tests on humans in the screening, diagnosis, or surveillance of OSCC or OPMDs and reporting sensitivity (SE) and specificity (SP). The Newcastle–Ottawa scale (NOS) was applied to assess the quality of the studies included. Results: The search strategy resulted in 8012 preliminary records. After a duplicate check, 116 titles remained. After abstract analysis, 70 papers remained. After full text analysis, only 54 of the 70 papers fit the inclusion criteria (28 were original articles and 26 were reviews). Those 26 reviews were used to manually search for further original articles. From this last search, 33 original articles were found. Thus, a total of 61 original studies were included and investigated. Findings from this systematic review indicate useful information, such as a description of the mechanisms, ease of use, limitations, and SE and SP values, to drive the choice of the optimal minimally invasive method to be utilized as an adjunctive tool to examine the suspicious lesions. Conclusions: Each of the analysed tools can be improved or implemented, considering their high SE and low SP. Despite advancements, incisional biopsy continues to be the gold standard for the definitive diagnosis of oral cancer and precancerous lesions. Further research and development are essential to improving the sensitivity, specificity, and reliability of non-invasive tools for widespread clinical application. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 14182033 2075-4418 |
| Relation: | https://www.mdpi.com/2075-4418/14/18/2033; https://doaj.org/toc/2075-4418 |
| DOI: | 10.3390/diagnostics14182033 |
| Access URL: | https://doaj.org/article/e0c598ccd9e843628c232f8c4d37d5d9 |
| Accession Number: | edsdoj.0c598ccd9e843628c232f8c4d37d5d9 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14182033 20754418 |
|---|---|
| DOI: | 10.3390/diagnostics14182033 |
| Published in: | Diagnostics |
| Language: | English |