Academic Journal
Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study.
| Title: | Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study. |
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| Authors: | Masamichi Komatsu, Hiroshi Yamamoto, Takashi Ichiyama, Satoshi Kawakami, Takeshi Uehara, Yumi Yoshikawa, Yoshiaki Kitaguchi, Atsuhito Ushiki, Masanori Yasuo, Masayuki Hanaoka |
| Source: | PLoS ONE, Vol 17, Iss 2, p e0262795 (2022) |
| Publisher Information: | Public Library of Science (PLoS), 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Idiopathic pulmonary fibrosis (IPF), a fibrosing interstitial lung disease, predominantly affects the elderly and is associated with a high mortality risk. Nintedanib, a tyrosine kinase inhibitor, significantly reduces IPF progression. However, data on the tolerability and efficacy of nintedanib in the elderly with IPF are limited. Therefore, this study aimed to examine the tolerability and efficacy of nintedanib in the elderly with IPF in a real-world setting. Medical records of 19 elderly IPF patients (≥ 75 years) and 46 non-elderly IPF patients (< 75 years) newly administered nintedanib were retrospectively analyzed. We compared the forced vital capacity (FVC) level, incidence and severity of adverse events, and continuation rates of nintedanib between the two groups. FVC and percent predicted diffusing capacity of the lung for carbon monoxide (DLco) were lower in the elderly IPF group at baseline. Although the elderly IPF patients had a significantly higher incidence of adverse events, such as diarrhea, nausea, and elevation of hepatic enzymes, the rate of discontinuation of nintedanib owing to adverse events was not different between the groups. The continuation rates of nintedanib treatment at 6 months and 1 year in the elderly IPF group were equivalent. Furthermore, there was a similar trend in the reduction of the annual FVC decline after nintedanib initiation between the groups. Our study demonstrated that nintedanib was tolerable in both the IPF patient groups in a real-world setting. Proper management of adverse events in the elderly with IPF would lead to a better clinical outcome. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0262795 |
| Access URL: | https://doaj.org/article/0bf6d8e87f2f4737881a6fcc8741112a |
| Accession Number: | edsdoj.0bf6d8e87f2f4737881a6fcc8741112a |
| Database: | Directory of Open Access Journals |
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| ISSN: | 19326203 |
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| DOI: | 10.1371/journal.pone.0262795 |
| Published in: | PLoS ONE |
| Language: | English |