Bibliographic Details
| Title: |
A Cultivated Form of a Red Seaweed (Chondrus crispus), Suppresses β-Amyloid-Induced Paralysis in Caenorhabditis elegans |
| Authors: |
Jatinder Singh Sangha, Owen Wally, Arjun H. Banskota, Roumiana Stefanova, Jeff T. Hafting, Alan T. Critchley, Balakrishnan Prithiviraj |
| Source: |
Marine Drugs, Vol 13, Iss 10, Pp 6407-6424 (2015) |
| Publisher Information: |
MDPI AG, 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
β-amyloid, Caenorhabditis elegans, cultivated Chondrus crispus, glycolipid, monogalactosyl diacylglycerol (MGDG), neuroprotection, red seaweeds, Biology (General), QH301-705.5 |
| More Details: |
We report here the protective effects of a methanol extract from a cultivated strain of the red seaweed, Chondrus crispus, against β-amyloid-induced toxicity, in a transgenic Caenorhabditis elegans, expressing human Aβ1-42 gene. The methanol extract of C. crispus (CCE), delayed β-amyloid-induced paralysis, whereas the water extract (CCW) was not effective. The CCE treatment did not affect the transcript abundance of amy1; however, Western blot analysis revealed a significant decrease of Aβ species, as compared to untreated worms. The transcript abundance of stress response genes; sod3, hsp16.2 and skn1 increased in CCE-treated worms. Bioassay guided fractionation of the CCE yielded a fraction enriched in monogalactosyl diacylglycerols (MGDG) that significantly delayed the onset of β-amyloid-induced paralysis. Taken together, these results suggested that the cultivated strain of C. crispus, whilst providing dietary nutritional value, may also have significant protective effects against β-amyloid-induced toxicity in C. elegans, partly through reduced β-amyloid species, up-regulation of stress induced genes and reduced accumulation of reactive oxygen species (ROS). |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1660-3397 |
| Relation: |
http://www.mdpi.com/1660-3397/13/10/6407; https://doaj.org/toc/1660-3397 |
| DOI: |
10.3390/md13106407 |
| Access URL: |
https://doaj.org/article/0bd8bc0d83e54848995705f5ebac8fa9 |
| Accession Number: |
edsdoj.0bd8bc0d83e54848995705f5ebac8fa9 |
| Database: |
Directory of Open Access Journals |
