Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults
| Title: | Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults |
|---|---|
| Authors: | Liangdong Zhou, Yi Li, Elizabeth M. Sweeney, Xiuyuan H. Wang, Amy Kuceyeski, Gloria C. Chiang, Jana Ivanidze, Yi Wang, Susan A. Gauthier, Mony J. de Leon, Thanh D. Nguyen |
| Source: | Frontiers in Aging Neuroscience, Vol 15 (2023) |
| Publisher Information: | Frontiers Media S.A., 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: | T2 relaxometry, cerebrospinal fluid fraction (CSFF), myelin water fraction (MWF), intra/extra-cellular water fraction (IEWF), FAST-T2, normal aging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: | Background and purposeOur objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20–80 years to study the effect of aging on the parenchymal CSF fraction (CSFF), a potential measure of the subvoxel CSF space.Materials and methodsA total of 60 volunteers (age range, 22–80 years) were enrolled. Voxel-wise maps of short-T2 myelin water fraction (MWF), intermediate-T2 intra/extra-cellular water fraction (IEWF), and long-T2 CSFF were obtained using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) sequence and three-pool non-linear least squares fitting. Multiple linear regression analyses were performed to study the association between age and regional MWF, IEWF, and CSFF measurements, adjusting for sex and region of interest (ROI) volume. ROIs include the cerebral white matter (WM), cerebral cortex, and subcortical deep gray matter (GM). In each model, a quadratic term for age was tested using an ANOVA test. A Spearman’s correlation between the normalized lateral ventricle volume, a measure of organ-level CSF space, and the regional CSFF, a measure of tissue-level CSF space, was computed.ResultsRegression analyses showed that there was a statistically significant quadratic relationship with age for CSFF in the cortex (p = 0.018), MWF in the cerebral WM (p = 0.033), deep GM (p = 0.017) and cortex (p = 0.029); and IEWF in the deep GM (p = 0.033). There was a statistically highly significant positive linear relationship between age and regional CSFF in the cerebral WM (p < 0.001) and deep GM (p < 0.001). In addition, there was a statistically significant negative linear association between IEWF and age in the cerebral WM (p = 0.017) and cortex (p < 0.001). In the univariate correlation analysis, the normalized lateral ventricle volume correlated with the regional CSFF measurement in the cerebral WM (ρ = 0.64, p < 0.001), cortex (ρ = 0.62, p < 0.001), and deep GM (ρ = 0.66, p < 0.001).ConclusionOur cross-sectional data demonstrate that brain tissue water in different compartments shows complex age-dependent patterns. Parenchymal CSFF, a measure of subvoxel CSF-like water in the brain tissue, is quadratically associated with age in the cerebral cortex and linearly associated with age in the cerebral deep GM and WM. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1663-4365 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1162001/full; https://doaj.org/toc/1663-4365 |
| DOI: | 10.3389/fnagi.2023.1162001 |
| Access URL: | https://doaj.org/article/0bb2151f3dfb410aad3fcac1a34e9636 |
| Accession Number: | edsdoj.0bb2151f3dfb410aad3fcac1a34e9636 |
| Database: | Directory of Open Access Journals |
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| Items | – Name: Title Label: Title Group: Ti Data: Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Liangdong+Zhou%22">Liangdong Zhou</searchLink><br /><searchLink fieldCode="AR" term="%22Yi+Li%22">Yi Li</searchLink><br /><searchLink fieldCode="AR" term="%22Elizabeth+M%2E+Sweeney%22">Elizabeth M. Sweeney</searchLink><br /><searchLink fieldCode="AR" term="%22Xiuyuan+H%2E+Wang%22">Xiuyuan H. Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Amy+Kuceyeski%22">Amy Kuceyeski</searchLink><br /><searchLink fieldCode="AR" term="%22Gloria+C%2E+Chiang%22">Gloria C. Chiang</searchLink><br /><searchLink fieldCode="AR" term="%22Jana+Ivanidze%22">Jana Ivanidze</searchLink><br /><searchLink fieldCode="AR" term="%22Yi+Wang%22">Yi Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Susan+A%2E+Gauthier%22">Susan A. Gauthier</searchLink><br /><searchLink fieldCode="AR" term="%22Mony+J%2E+de+Leon%22">Mony J. de Leon</searchLink><br /><searchLink fieldCode="AR" term="%22Thanh+D%2E+Nguyen%22">Thanh D. Nguyen</searchLink> – Name: TitleSource Label: Source Group: Src Data: Frontiers in Aging Neuroscience, Vol 15 (2023) – Name: Publisher Label: Publisher Information Group: PubInfo Data: Frontiers Media S.A., 2023. – Name: DatePubCY Label: Publication Year Group: Date Data: 2023 – Name: Subset Label: Collection Group: HoldingsInfo Data: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22T2+relaxometry%22">T2 relaxometry</searchLink><br /><searchLink fieldCode="DE" term="%22cerebrospinal+fluid+fraction+%28CSFF%29%22">cerebrospinal fluid fraction (CSFF)</searchLink><br /><searchLink fieldCode="DE" term="%22myelin+water+fraction+%28MWF%29%22">myelin water fraction (MWF)</searchLink><br /><searchLink fieldCode="DE" term="%22intra%2Fextra-cellular+water+fraction+%28IEWF%29%22">intra/extra-cellular water fraction (IEWF)</searchLink><br /><searchLink fieldCode="DE" term="%22FAST-T2%22">FAST-T2</searchLink><br /><searchLink fieldCode="DE" term="%22normal+aging%22">normal aging</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%2E+Biological+psychiatry%2E+Neuropsychiatry%22">Neurosciences. Biological psychiatry. Neuropsychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22RC321-571%22">RC321-571</searchLink> – Name: Abstract Label: Description Group: Ab Data: Background and purposeOur objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20–80 years to study the effect of aging on the parenchymal CSF fraction (CSFF), a potential measure of the subvoxel CSF space.Materials and methodsA total of 60 volunteers (age range, 22–80 years) were enrolled. Voxel-wise maps of short-T2 myelin water fraction (MWF), intermediate-T2 intra/extra-cellular water fraction (IEWF), and long-T2 CSFF were obtained using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) sequence and three-pool non-linear least squares fitting. Multiple linear regression analyses were performed to study the association between age and regional MWF, IEWF, and CSFF measurements, adjusting for sex and region of interest (ROI) volume. ROIs include the cerebral white matter (WM), cerebral cortex, and subcortical deep gray matter (GM). In each model, a quadratic term for age was tested using an ANOVA test. A Spearman’s correlation between the normalized lateral ventricle volume, a measure of organ-level CSF space, and the regional CSFF, a measure of tissue-level CSF space, was computed.ResultsRegression analyses showed that there was a statistically significant quadratic relationship with age for CSFF in the cortex (p = 0.018), MWF in the cerebral WM (p = 0.033), deep GM (p = 0.017) and cortex (p = 0.029); and IEWF in the deep GM (p = 0.033). There was a statistically highly significant positive linear relationship between age and regional CSFF in the cerebral WM (p < 0.001) and deep GM (p < 0.001). In addition, there was a statistically significant negative linear association between IEWF and age in the cerebral WM (p = 0.017) and cortex (p < 0.001). In the univariate correlation analysis, the normalized lateral ventricle volume correlated with the regional CSFF measurement in the cerebral WM (ρ = 0.64, p < 0.001), cortex (ρ = 0.62, p < 0.001), and deep GM (ρ = 0.66, p < 0.001).ConclusionOur cross-sectional data demonstrate that brain tissue water in different compartments shows complex age-dependent patterns. Parenchymal CSFF, a measure of subvoxel CSF-like water in the brain tissue, is quadratically associated with age in the cerebral cortex and linearly associated with age in the cerebral deep GM and WM. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article – Name: Format Label: File Description Group: SrcInfo Data: electronic resource – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 1663-4365 – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://www.frontiersin.org/articles/10.3389/fnagi.2023.1162001/full; https://doaj.org/toc/1663-4365 – Name: DOI Label: DOI Group: ID Data: 10.3389/fnagi.2023.1162001 – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/0bb2151f3dfb410aad3fcac1a34e9636" linkWindow="_blank">https://doaj.org/article/0bb2151f3dfb410aad3fcac1a34e9636</link> – Name: AN Label: Accession Number Group: ID Data: edsdoj.0bb2151f3dfb410aad3fcac1a34e9636 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fnagi.2023.1162001 Languages: – Text: English Subjects: – SubjectFull: T2 relaxometry Type: general – SubjectFull: cerebrospinal fluid fraction (CSFF) Type: general – SubjectFull: myelin water fraction (MWF) Type: general – SubjectFull: intra/extra-cellular water fraction (IEWF) Type: general – SubjectFull: FAST-T2 Type: general – SubjectFull: normal aging Type: general – SubjectFull: Neurosciences. Biological psychiatry. Neuropsychiatry Type: general – SubjectFull: RC321-571 Type: general Titles: – TitleFull: Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Liangdong Zhou – PersonEntity: Name: NameFull: Yi Li – PersonEntity: Name: NameFull: Elizabeth M. Sweeney – PersonEntity: Name: NameFull: Xiuyuan H. Wang – PersonEntity: Name: NameFull: Amy Kuceyeski – PersonEntity: Name: NameFull: Gloria C. Chiang – PersonEntity: Name: NameFull: Jana Ivanidze – PersonEntity: Name: NameFull: Yi Wang – PersonEntity: Name: NameFull: Susan A. Gauthier – PersonEntity: Name: NameFull: Mony J. de Leon – PersonEntity: Name: NameFull: Thanh D. Nguyen IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 16634365 Numbering: – Type: volume Value: 15 Titles: – TitleFull: Frontiers in Aging Neuroscience Type: main |
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