Bibliographic Details
| Title: |
Optimal perioperative flomoxef administration interval in hepatobiliary-pancreatic surgery |
| Authors: |
Yoko Takayama, Toshiaki Komatsu |
| Source: |
Journal of Global Antimicrobial Resistance, Vol 39, Iss , Pp 24- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
serum concentration, flomoxef, dosing interval, renal function, hepatobiliary-pancreatic surgery, Microbiology, QR1-502 |
| More Details: |
AIM: To clarify the optimal perioperative prophylactic flomoxef (FMOX) interval. BACKGROUND: Perioperative prophylactic antimicrobials are readministered at intervals of twice their half-life. However, the actual concentrations of antimicrobial agents and the degree of accumulation have not been determined. METHODS: FMOX, also known as oxacephem, is a β-lactam antibiotic with broad-spectrum antibacterial activity against gram-positive and gram-negative aerobic and anaerobic bacteria. Serum concentrations were evaluated in patients who underwent hepatobiliary-pancreatic surgery between April 2019 and December 2020 and received an additional dose of FMOX every 3 h or 5 h during the surgical procedure based on their renal function. RESULTS: Among the 31 patients (Table), 25 (with creatinine clearance [Ccr] >60 mL/min in 18 and ≤60 mL/min in 7) and 6 (Ccr ≤60 mL/min) received FMOX every 3 h and 5 h, respectively. Of the 25 patients with a creatinine clearance (Ccr) >60 mL/min, 18 had serum FMOX concentrations of 9.56 ± 2.60 mg/L and 9.98 ± 2.99 mg/L (p = 0.07). For the 7 patients with Ccr ≤60 mL/min, serum FMOX levels were 16.70 ± 6.63 mg/L and 21.83 ± 7.95 mg/L (p < 0.01), respectively. When comparing FMOX dosing intervals, median concentrations were 9.85 mg/L (Ccr >60 mL/min) at 6 h, compared to 12.85 mg/L at 6 h and 20.03 mg/L (Ccr ≤60 mL/min) at 5 h for Ccr ≤60 mL/min, respectively (Fig. A, B). CONCLUSIONS: Administering FMOX every 3 h when Ccr ≥ 60 mL/min and every 5 h when Ccr < 60 mL/min is appropriate. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2213-7165 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2213716524002509; https://doaj.org/toc/2213-7165 |
| DOI: |
10.1016/j.jgar.2024.10.073 |
| Access URL: |
https://doaj.org/article/a0ba14faa619460b93df98c88064a60a |
| Accession Number: |
edsdoj.0ba14faa619460b93df98c88064a60a |
| Database: |
Directory of Open Access Journals |
