Academic Journal
Pattern of microbial translocation in patients living with HIV‐1 from Vietnam, Ethiopia and Sweden
| Title: | Pattern of microbial translocation in patients living with HIV‐1 from Vietnam, Ethiopia and Sweden |
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| Authors: | Samir Abdurahman, Babilonia Barqasho, Piotr Nowak, Do Duy Cuong, Wondwossen Amogne, Mattias Larsson, Lars Lindquist, Gaetano Marrone, Anders Sönnerborg |
| Source: | Journal of the International AIDS Society, Vol 17, Iss 1, Pp n/a-n/a (2014) |
| Publisher Information: | Wiley, 2014. |
| Publication Year: | 2014 |
| Collection: | LCC:Immunologic diseases. Allergy |
| Subject Terms: | microbial translocation, immune activation, LPS, sCD14, treatment‐naïve patients living with HIV, HIV in Vietnam, Immunologic diseases. Allergy, RC581-607 |
| More Details: | Introduction The role of microbial translocation (MT) in HIV patients living with HIV from low‐ and middle‐income countries (LMICs) is not fully known. The aim of this study is to investigate and compare the patterns of MT in patients from Vietnam, Ethiopia and Sweden. Methods Cross‐sectional samples were obtained from treatment‐naïve patients living with HIV‐1 and healthy controls from Vietnam (n=83; n=46), Ethiopia (n=9492; n=50) and Sweden (n=51; n=19). Longitudinal samples were obtained from a subset of the Vietnamese (n=24) in whom antiretroviral therapy (ART) and tuberculostatics were given. Plasma lipopolysaccharide (LPS), sCD14 and anti‐flagellin IgG were determined by the endpoint chromogenic Limulus Amebocyte Assay and enzyme‐linked immunosorbent assay. Results All three biomarkers were significantly increased in patients living with HIV‐1 from all countries as compared to controls. No differences were found between males and females. Vietnamese and Ethiopian patients had significantly higher levels of anti‐flagellin IgG and LPS, as compared to Swedes. ART reduced these levels for the Vietnamese. Vietnamese patients given tuberculostatics at initiation of ART had significantly lower levels of anti‐flagellin IgG and higher sCD14. The biomarkers were lower in Vietnamese who did not develop opportunistic infection. Conclusions Higher MT is common in patients living with HIV compared to healthy individuals, and in patients from LMICs compared to patients from a high‐income country. Treatment with tuberculostatics decreased MT while higher levels of MT are associated with a poorer clinical outcome. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1758-2652 89010949 |
| Relation: | https://doaj.org/toc/1758-2652 |
| DOI: | 10.7448/IAS.17.1.18841 |
| Access URL: | https://doaj.org/article/0b85ad89010949f79d321b5d1128c5ea |
| Accession Number: | edsdoj.0b85ad89010949f79d321b5d1128c5ea |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17582652 89010949 |
|---|---|
| DOI: | 10.7448/IAS.17.1.18841 |
| Published in: | Journal of the International AIDS Society |
| Language: | English |