Bibliographic Details
| Title: |
Comparing HLA shared epitopes in French Caucasian patients with scleroderma. |
| Authors: |
Doua F Azzouz, Justyna M Rak, Isabelle Fajardy, Yannick Allanore, Kiet Phong Tiev, Dominique Farge-Bancel, Marielle Martin, Sami B Kanaan, Philippe P Pagni, Eric Hachulla, Jean Robert Harlé, Rémi Didelot, Brigitte Granel, Jean Cabane, Jean Roudier, Nathalie C Lambert |
| Source: |
PLoS ONE, Vol 7, Iss 5, p e36870 (2012) |
| Publisher Information: |
Public Library of Science (PLoS), 2012. |
| Publication Year: |
2012 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Although many studies have analyzed HLA allele frequencies in several ethnic groups in patients with scleroderma (SSc), none has been done in French Caucasian patients and none has evaluated which one of the common amino acid sequences, (67)FLEDR(71), shared by HLA-DRB susceptibility alleles, or (71)TRAELDT(77), shared by HLA-DQB1 susceptibility alleles in SSc, was the most important to develop the disease. HLA-DRB and DQB typing was performed for a total of 468 healthy controls and 282 patients with SSc allowing FLEDR and TRAELDT analyses. Results were stratified according to patient's clinical subtypes and autoantibody status. Moreover, standardized HLA-DRß1 and DRß5 reverse transcriptase Taqman PCR assays were developed to quantify ß1 and ß5 mRNA in 20 subjects with HLA-DRB1*15 and/or DRB1*11 haplotypes. FLEDR motif is highly associated with diffuse SSc (χ(2) = 28.4, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC3352938?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0036870 |
| Access URL: |
https://doaj.org/article/0b64ed02720b4926a6d19776e6caa38a |
| Accession Number: |
edsdoj.0b64ed02720b4926a6d19776e6caa38a |
| Database: |
Directory of Open Access Journals |
