Bibliographic Details
| Title: |
Post-marketing surveilance study of creatine-guanidinoacetic acid safety in healthy adults |
| Authors: |
Marijana Ranisavljev, Nikola Todorovic, Valdemar Stajer, Sergej M. Ostojic |
| Source: |
Frontiers in Nutrition, Vol 11 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
creatine, guanidinoacetic acid, homocysteine, adverse events, safety, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
A post-marketing surveillance study assessed the adverse events and possible risk of elevated homocysteine levels after the supplementation with creatine-guanidinoacetic acid mixture in apparently healthy adults. The participants were recruited through social media platforms and online discussion boards, with side effects and total plasma homocysteine (T-Hcy) levels evaluated regularly during a supplementation period of 6 months. Thirthy eight individuals (n = 38, 34.2% female) completed the evaluation period and were included in the final analyses. Serious side effects were absent. Two participants (5.3%) reported transitional nausea during the introductory weeks of the supplementation; no participants stopped the treatment. Baseline T-Hcy levels were 11.6 ± 3.1 μmol/L (95% confidence interval [CI], from 10.6 to 12.6). The intervention induced a mild reduction in T-Hcy levels across the monitoring period (p = 0.028), with T-Hcy levels after 1, 2, 3, and 6 months were 10.4 ± 3.0 μmol/L, 10.6 ± 2.9 μmol/L, 10.1 ± 2.7 μmol/L, and 9.3 ± 2.8 μmol/L, respectively. These findings suggest the overall tolerability of creatine-guanidinoacetic mixture in healthy adults, with homocysteine-increasing risk of no concern. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-861X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnut.2024.1414308/full; https://doaj.org/toc/2296-861X |
| DOI: |
10.3389/fnut.2024.1414308 |
| Access URL: |
https://doaj.org/article/0b5dbd56137840ca9c0ff0b787a5f89b |
| Accession Number: |
edsdoj.0b5dbd56137840ca9c0ff0b787a5f89b |
| Database: |
Directory of Open Access Journals |
