Academic Journal
Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians
| Title: | Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians |
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| Authors: | Claudia H. T. Tam, Cadmon K. P. Lim, Andrea O. Y. Luk, Alex C. W. Ng, Heung-man Lee, Guozhi Jiang, Eric S. H. Lau, Baoqi Fan, Raymond Wan, Alice P. S. Kong, Wing-hung Tam, Risa Ozaki, Elaine Y. K. Chow, Ka-fai Lee, Shing-chung Siu, Grace Hui, Chiu-chi Tsang, Kam-piu Lau, Jenny Y. Y. Leung, Man-wo Tsang, Grace Kam, Ip-tim Lau, June K. Y. Li, Vincent T. F. Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk-lun Cheng, Chun-chung Chow, Miao Hu, Weichuan Yu, Stephen K. W. Tsui, Yu Huang, Huiyao Lan, Cheuk-chun Szeto, Nelson L. S. Tang, Maggie C. Y. Ng, Wing-yee So, Brian Tomlinson, Juliana C. N. Chan, Ronald C. W. Ma, The Hong Kong Diabetes Register TRS Study Group, The Hong Kong Diabetes Biobank Study Group |
| Source: | Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021) |
| Publisher Information: | BMC, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine LCC:Genetics |
| Subject Terms: | Polygenic risk scores, Lipid traits, Subclinical atherosclerosis, Diabetes cardiovascular complications, East Asians, Medicine, Genetics, QH426-470 |
| More Details: | Abstract Background The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear. Methods We used data from Biobank Japan (n = 70,657–128,305) and developed novel East Asian-specific genome-wide polygenic risk scores (PRSs) for four lipid traits. We validated (n = 4271) and subsequently tested associations of these scores with 3-year lipid changes in adolescents (n = 620), carotid intima-media thickness (cIMT) in adult women (n = 781), dyslipidemia (n = 7723), and coronary heart disease (CHD) (n = 2374 cases and 6246 controls) in type 2 diabetes (T2D) patients. Results Our PRSs aggregating 84–549 genetic variants (0.251 |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1756-994X |
| Relation: | https://doaj.org/toc/1756-994X |
| DOI: | 10.1186/s13073-021-00831-z |
| Access URL: | https://doaj.org/article/0b2ae016f2954b74aecee230cb5cdc4f |
| Accession Number: | edsdoj.0b2ae016f2954b74aecee230cb5cdc4f |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1756994X |
|---|---|
| DOI: | 10.1186/s13073-021-00831-z |
| Published in: | Genome Medicine |
| Language: | English |