Aqueous proinflammatory cytokines in acute primary angle-closure eyes
| Title: | Aqueous proinflammatory cytokines in acute primary angle-closure eyes |
|---|---|
| Authors: | Yao-Ming Liu, Shi-Da Chen, Xing-Yi Li, Wen-Bin Huang, Fei Li, Jia-Wei Wang, Ying-Qi Li, Xiu-Lan Zhang |
| Source: | International Journal of Ophthalmology, Vol 10, Iss 5, Pp 733-737 (2017) |
| Publisher Information: | Press of International Journal of Ophthalmology (IJO PRESS), 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Ophthalmology |
| Subject Terms: | 737, acute primary angle-closure, aqueous humor, inflammation, cytokines, Ophthalmology, RE1-994 |
| More Details: | AIM: To evaluate changes of proinflammatory cytokines in aqueous humor of patients with acute primary angle-closure (APAC) and age-related cataracts. METHODS: Twenty eyes of 20 APAC patients and 15 eyes of 15 age-related cataract patients were included in this cross-sectional study. Aqueous humor samples were collected prospectively. The levels of 20 proinflammatory cytokines were evaluated in the aqueous humor of the APAC and cataract patients using the multiplex bead immunoassay technique. Clinical data were collected for correlation analysis. RESULTS: Seven of the 20 proinflammatory cytokines included in the magnetic bead panel were detectable in both APAC eyes and cataract eyes: interleukin (IL)-10, IL-12, IL-15, IL-21, IL-6, chemokine (C-C motif) ligand 20, and tumor necrosis factor alpha (TNF-α). IL-27 was only detectable in APAC eyes. Compared with the cataract eyes, the APAC eyes had significantly elevated concentrations of IL-12 (P=0.036), IL-15 (P=0.001), IL-6 (P=0.012), and IL-27 (only detectable in APAC eyes). Age was positively correlated with IL-12 (P=0.022) and IL-6 (P=0.037), and time elapsed between APAC onset and aqueous humor samples collection was positively correlated with IL-15 (P=0.037), IL-27 (P=0.040), and TNF-α (P=0.042). CONCLUSION: Several proinflammatory cytokines including IL-12，IL-15, IL-6 and IL-27, were elevated in the APAC eyes and may be implicated in its pathologic mechanism. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2222-3959 2227-4898 |
| Relation: | http://www.ijo.cn/en_publish/2017/5/20170512.pdf; https://doaj.org/toc/2222-3959; https://doaj.org/toc/2227-4898 |
| DOI: | 10.18240/ijo.2017.05.12 |
| Access URL: | https://doaj.org/article/0b17898b7e6e4dc6a26e5c16fe7dcb8e |
| Accession Number: | edsdoj.0b17898b7e6e4dc6a26e5c16fe7dcb8e |
| Database: | Directory of Open Access Journals |
| ISSN: | 22223959 22274898 |
|---|---|
| DOI: | 10.18240/ijo.2017.05.12 |
| Published in: | International Journal of Ophthalmology |
| Language: | English |