Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth
| Title: | Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth |
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| Authors: | Mark David Hayes, Sophie Ward, Greg Crawford, Rocio Castro Seoane, William David Jackson, David Kipling, David Voehringer, Deborah Dunn-Walters, Jessica Strid |
| Source: | eLife, Vol 9 (2020) |
| Publisher Information: | eLife Sciences Publications Ltd, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Medicine LCC:Science LCC:Biology (General) |
| Subject Terms: | skin, IgE, epithelial cells, inflammation, cancer, basophils, Medicine, Science, Biology (General), QH301-705.5 |
| More Details: | IgE is the least abundant circulating antibody class but is constitutively present in healthy tissues bound to resident cells via its high-affinity receptor, FcεRI. The physiological role of endogenous IgE antibodies is unclear but it has been suggested that they provide host protection against a variety of noxious environmental substances and parasitic infections at epithelial barrier surfaces. Here we show, in mice, that skin inflammation enhances levels of IgE antibodies that have natural specificities and a repertoire, VDJ rearrangements and CDRH3 characteristics similar to those of IgE antibodies in healthy tissue. IgE-bearing basophils are recruited to inflamed skin via CXCL12 and thymic stromal lymphopoietin (TSLP)/IL-3-dependent upregulation of CXCR4. In the inflamed skin, IgE/FcεRI-signalling in basophils promotes epithelial cell growth and differentiation, partly through histamine engagement of H1R and H4R. Furthermore, this IgE response strongly drives tumour outgrowth of epithelial cells harbouring oncogenic mutation. These findings indicate that natural IgE antibodies support skin barrier defences, but that during chronic tissue inflammation this role may be subverted to promote tumour growth. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2050-084X |
| Relation: | https://elifesciences.org/articles/51862; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.51862 |
| Access URL: | https://doaj.org/article/0b0bfa2ee5464967811018518a8262c3 |
| Accession Number: | edsdoj.0b0bfa2ee5464967811018518a8262c3 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2050084X |
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| DOI: | 10.7554/eLife.51862 |
| Published in: | eLife |
| Language: | English |