Bibliographic Details
| Title: |
A novel histone acetylation-associated gene signature with prognostic value in Ewing sarcoma |
| Authors: |
Anshun Wu, Fayin Liu, Lei Zhou, Runyi Jiang, Shangjiang Yu, Zihuan Zhou, Qi Zhang, Qian Zhang, Dongjie Jiang, Shaohui He, Haifeng Wei |
| Source: |
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024) |
| Publisher Information: |
Springer, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Ewing sarcoma, Histone acetylation, HDAC2, Prognostic signature, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Histone acetylation is an important epigenetic modification, modulating the development of many tumors. However, the functions of most histone acetylation-related genes (HARGs) and their prognostic values in Ewing sarcoma (EWS) remain unclear. The current study aimed to investigate the prognostic values and potential functions of HARGs in EWS. After collecting EWS patients with mRNA sequencing data from the Gene Expression Omnibus (GEO) database and a list of HARGs from previous studies, Cox regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression were performed to construct a prognostic gene signature based on HARGs. Then, four HARGs (TAF4, ATF2, HDAC2 and OGA) composed a formula to calculate risk score for each patient in the training cohort. Based on median risk score, all patients were classified into low- and high-risk group, and patients with high-risk score had a poor survival outcome (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2730-6011 |
| Relation: |
https://doaj.org/toc/2730-6011 |
| DOI: |
10.1007/s12672-024-01689-4 |
| Access URL: |
https://doaj.org/article/0afeb7e6a2624e538cef9b91f6ed1f94 |
| Accession Number: |
edsdoj.0afeb7e6a2624e538cef9b91f6ed1f94 |
| Database: |
Directory of Open Access Journals |
