Academic Journal
Young obese patients may benefit from GnRH-a long protocol contributing to higher implantation rate and live birth rate of fresh IVF-ET cycles
| Title: | Young obese patients may benefit from GnRH-a long protocol contributing to higher implantation rate and live birth rate of fresh IVF-ET cycles |
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| Authors: | Qi Wan, Yue Qian, Ming-Jing Xia, Li Tan, Xing-Yu Lv, Xiang-Qian Meng, Yu-Bin Ding, Zhao-Hui Zhong, Li-Hong Geng |
| Source: | Heliyon, Vol 9, Iss 10, Pp e20016- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | Obesity, IVF-ET, COH protocol, Pregnancy outcome, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | Introduction: Obesity has detrimental influences on women reproductive health. There is little experience in optimizing controlled ovarian hyperstimulation (COH) protocols to treat Chinese obese patients who are undergoing in vitro fertilization and embryo transfer (IVF-ET) therapy. Methods: The clinical outcome differences were retrospectively analyzed among obese patients who received gonadotrophin-releasing hormone agonist (GnRH-a), GnRH antagonist (GnRH-ant), micro dose GnRH-a (mGnRH-a) and GnRH-a long protocol in IVF-ET cycle at Chengdu Jinjiang Hospital for Women's and Children's Health from January 2014 to December 2019. Results: The transplantation rate of the GnRH-a long protocol group (59.1%) was higher than that of the GnRH-ant (25.9%) and mGnRH-a (36.7%) groups. The total live birth rate of the GnRH-a long protocol group (46.2%) was higher than that of the GnRH-a group (25.9%) and GnRH-ant group (40.3%). The total number of frozen embryos in the GnRH-ant group was higher than in the other groups (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023072249; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e20016 |
| Access URL: | https://doaj.org/article/0aeb4e06d0cc4888898e6e891de4d41b |
| Accession Number: | edsdoj.0aeb4e06d0cc4888898e6e891de4d41b |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e20016 |
| Published in: | Heliyon |
| Language: | English |