Bibliographic Details
| Title: |
Copper-based fluorinated reagents for the synthesis of CF2R-containing molecules (R ≠ F) |
| Authors: |
Louise Ruyet, Tatiana Besset |
| Source: |
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1051-1065 (2020) |
| Publisher Information: |
Beilstein-Institut, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science
LCC:Organic chemistry |
| Subject Terms: |
copper, difluoromethylation, fluorinated reagents, fluorine chemistry, synthetic methodologies, Science, Organic chemistry, QD241-441 |
| More Details: |
Over the years, the development of new methodologies for the introduction of various fluorinated motifs has gained a significant interest due to the importance of fluorine-containing molecules in the pharmaceutical and agrochemical industries. In a world eager to eco-friendlier tools, the need for innovative methods has been growing. To address these two challenges, copper-based reagents were developed to introduce CF2H, CF2RF, CF2CH3, CF2PO(OEt)2 and CF2SO2Ph motifs on a broad range of substrates. Copper-based fluorinated reagents have the advantage of being inexpensive and generally in situ generated or prepared in a few steps, which make them convenient to use. In this review, an overview of the recent advances made for the synthesis of fluorinated molecules using copper-based fluorinated reagents will be given. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1860-5397 |
| Relation: |
https://doaj.org/toc/1860-5397 |
| DOI: |
10.3762/bjoc.16.92 |
| Access URL: |
https://doaj.org/article/0acb605866da4035a03d0d5c12db30d3 |
| Accession Number: |
edsdoj.0acb605866da4035a03d0d5c12db30d3 |
| Database: |
Directory of Open Access Journals |
