| Title: |
The relationship between serum oestrogen levels and clinical outcomes of hormone replacement therapy-frozen embryo transfer: a retrospective clinical study |
| Authors: |
Na Kong, Jingyu Liu, Chunxue Zhang, Yue Jiang, Yingchun Zhu, Guijun Yan, Haixiang Sun, Chenyang Huang |
| Source: |
BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-8 (2022) |
| Publisher Information: |
BMC, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Gynecology and obstetrics |
| Subject Terms: |
Clinical pregnancy rate, Endometrial transformation, Endometrial thicknesses, Hormone replacement therapy-frozen embryo transfer, Serum oestrogen levels, Gynecology and obstetrics, RG1-991 |
| More Details: |
Abstract Background This study aimed to explore the relationship between serum oestrogen (E2) levels before endometrial transformation and pregnancy outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) cycles, which has been investigated for years without any consensus. Methods A retrospective cohort study of 10,209 cycles HRT-FET cycles was conducted at the Reproductive Medicine Center of Nanjing Drum Tower Hospital from March 2017 to December 2020. A smooth fitting curve was constructed to identify the relationship between serum E2 levels before endometrial transformation and the clinical pregnancy rate. Then, threshold and saturation effect analysis was employed to explore the cut-off value of serum E2 levels. In addition, patients were divided into 2 groups based on their levels of serum E2 measured before progesterone-induced endometrial transformation: Group 1, < 300 pg/mL (n = 6251) and Group 2, ≥ 300 pg/mL (n = 3958). The clinical pregnancy and miscarriage rates of all groups were compared. Further smooth fitting curve analysis was employed by different subgroups segmented according to different endometrial thicknesses. Results When the serum E2 level was greater than 300 pg/mL, the clinical pregnancy rate decreased significantly (62.9% vs. 59.8%, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2393 |
| Relation: |
https://doaj.org/toc/1471-2393 |
| DOI: |
10.1186/s12884-022-04605-2 |
| Access URL: |
https://doaj.org/article/0a850584eb2f4b97baeb60c5b025a5ff |
| Accession Number: |
edsdoj.0a850584eb2f4b97baeb60c5b025a5ff |
| Database: |
Directory of Open Access Journals |
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