Bibliographic Details
| Title: |
Cytoprotective organoselenium compounds for oligodendrocytes |
| Authors: |
Saad Shaaban, Amira Zarrouk, Dominique Vervandier-Fasseur, Yasair S.Al-Faiyz, Hany El-Sawy, Ismail Althagafi, Pierre Andreoletti, Mustapha Cherkaoui-Malki |
| Source: |
Arabian Journal of Chemistry, Vol 14, Iss 4, Pp 103051- (2021) |
| Publisher Information: |
Elsevier, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Chemistry |
| Subject Terms: |
Organoselenium, Ugi reaction, Tetrazole, Antioxidant, Oligodendrocytes, Cytoprotective, Chemistry, QD1-999 |
| More Details: |
Herein we report the synthesis of peptide-like and tetrazole-based organoselenium compounds via Ugi and Ugi-azide reactions, respectively. The organoselenium compounds' intrinsic cytoprotective and antioxidant capacities were evaluated in 158 N and 158JP murine oligodendrocytes. Furthermore, their redox properties were theoretically evaluated using Molecular Operating Environment-docking studies. Most of the compounds did not exhibit any cytotoxicity against the 158JP and 158 N cells. Among the tested compounds, the tetrazole- (e.g., 6, 7, and 9) and the pseudopeptide-based organoselenium compounds (e.g., 11, 15, and 17) displayed antioxidant properties. On the other hand, the quinones- (e.g., 4c and 18) and the pseudopeptides-based (e.g., 12, 14, and 17) organoselenium compounds exhibited prooxidant activities. Furthermore, the tetrazole-based organoselenium compounds 5 and 9 and the selenopeptide 11 and 15 showed good GPx-like activity. Some of the newly synthesized organoselenium compounds presented interesting antioxidant and cytoprotective activities and are therefore considered potential myelin diseases drug candidates. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1878-5352 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1878535221000666; https://doaj.org/toc/1878-5352 |
| DOI: |
10.1016/j.arabjc.2021.103051 |
| Access URL: |
https://doaj.org/article/09f95b8a70e54b9997e542b8e47f7b73 |
| Accession Number: |
edsdoj.09f95b8a70e54b9997e542b8e47f7b73 |
| Database: |
Directory of Open Access Journals |
