Bibliographic Details
| Title: |
Integration of antimicrobial stewardship intervention with rapid organism identification improve outcomes in adult patients with bloodstream infections |
| Authors: |
Tzu-Ping Weng, Ching-Lung Lo, Wen-Liang Lin, Jen-Chieh Lee, Ming-Chi Li, Wen-Chien Ko, Nan-Yao Lee |
| Source: |
Journal of Microbiology, Immunology and Infection, Vol 56, Iss 1, Pp 57-63 (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
Bloodstream infection, Antimicrobial stewardship intervention, MALDI-TOF-MS, Microbiology, QR1-502 |
| More Details: |
Background: Integration of antimicrobial stewardship intervention (ASI) with rapid organism identification has the potential for early customization of antimicrobial therapy and improved clinical outcomes. We aimed to evaluate the impact of this combined approach on antimicrobial therapy-related outcomes in patients with bloodstream infections (BSIs). Materials and methods: A pre–post quasi-experimental study was conducted to analyze the impact of ASI with organism identification via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) among patients with BSIs. Outcomes were compared to a historic pre-intervention group. The 30-day mortality was the primary endpoint. Secondary outcomes included time to first antibiotic modification, length of hospital stay. Results: A total of 1004 adult patients with BSIs were included in the final analysis, 519 patients classified into the intervention group and 485 patients in the preintervention group. The patients in the intervention group were younger (66 vs. 70 years, P = 0.02). The 30-day crude mortality (14.6% vs. 29.9%, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1684-1182 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1684118222001001; https://doaj.org/toc/1684-1182 |
| DOI: |
10.1016/j.jmii.2022.07.002 |
| Access URL: |
https://doaj.org/article/d09c0d42476a4999aa28721a13fb51f4 |
| Accession Number: |
edsdoj.09c0d42476a4999aa28721a13fb51f4 |
| Database: |
Directory of Open Access Journals |
