Bibliographic Details
| Title: |
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation |
| Authors: |
Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
RIPK1 kinase activity is known to transduce a death signal, but the molecular mechanisms that normally prevent RIPK1 activation are unclear. Here, the authors report that IKK-mediated phosphorylation on RIPK1 Ser25 directly represses its enzymatic activity and thus RIPK1-dependent cell death. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-09690-0 |
| Access URL: |
https://doaj.org/article/09b6a96e862a47278fdf07e7af978602 |
| Accession Number: |
edsdoj.09b6a96e862a47278fdf07e7af978602 |
| Database: |
Directory of Open Access Journals |
