Bibliographic Details
| Title: |
The role of nanomaterials in enhancing natural product translational potential and modulating endoplasmic reticulum stress in the treatment of ovarian cancer |
| Authors: |
Rajeev K. Singla, Pooja Sharma, Dinesh Kumar, Rupesh K. Gautam, Rajat Goyal, Christos Tsagkaris, Ankit Kumar Dubey, Himangini Bansal, Rohit Sharma, Bairong Shen |
| Source: |
Frontiers in Pharmacology, Vol 13 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
ovaries, natural compounds, ovarian neoplasms, nanotechnology, phytomedicine, ER stress, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Ovarian cancer, and particularly its most frequent type, epithelial ovarian carcinoma, constitutes one of the most dangerous malignant tumors among females. Substantial evidence has described the potential of phytochemicals against ovarian cancer. The effect of natural compounds on endoplasmic reticulum (ER) stress is of great relevance in this regard. In ovarian cancer, the accumulation of misfolded proteins in the ER lumen results in decompensated ER stress. This leads to deregulation in the physiological processes for the posttranslational modification of proteins, jeopardizes cellular homeostasis, and increases apoptotic signaling. Several metabolites and metabolite extracts of phytochemical origin have been studied in the context of ER stress in ovarian cancer. Resveratrol, quercetin, curcumin, fucosterol, cleistopholine, fucoidan, and epicatechin gallate, among others, have shown inhibitory potential against ER stress. The chemical structure of each compound plays an important role concerning its pharmacodynamics, pharmacokinetics, and overall effectiveness. Studying and cross-comparing the chemical features that render different phytochemicals effective in eliciting particular anti-ER stress actions can help improve drug design or develop multipotent combination regimens. Many studies have also investigated the properties of formulations such as nanoparticles, niosomes, liposomes, and intravenous hydrogel based on curcumin and quercetin along with some other phytomolecules in ovarian cancer. Overall, the potential of phytochemicals in targeting genetic mechanisms of ovarian cancer warrants further translational and clinical investigation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1663-9812 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fphar.2022.987088/full; https://doaj.org/toc/1663-9812 |
| DOI: |
10.3389/fphar.2022.987088 |
| Access URL: |
https://doaj.org/article/09acf08b9efc44b8a80775778df727ca |
| Accession Number: |
edsdoj.09acf08b9efc44b8a80775778df727ca |
| Database: |
Directory of Open Access Journals |
