Association of Neuregulin-4 levels and body mass index with hyperandrogenism in Polycystic Ovary Syndrome patients
| Title: | Association of Neuregulin-4 levels and body mass index with hyperandrogenism in Polycystic Ovary Syndrome patients |
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| Authors: | mustafa Mutashar, Dr. Manal Kamal Rasheed, Dr. Afraa Mahjoba Al-Naddawi |
| Source: | مجلة كلية الطب, Vol 65, Iss 4 (2024) |
| Publisher Information: | College of Medicine University of Baghdad, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | Neuregulin 4, BMI, Polycystic Ovary Syndrome, Free testosterone, Medicine, Medicine (General), R5-920 |
| More Details: | Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disease that affects approximately 15% of women of childbearing age worldwide. It is one of the causes of infertility and is characterized by hirsutism, acne, persistent or interrupted anovulation, and hyperandrogenemia. Neuregulin-4 (NRG-4) is an adipokine hormone from the protein neuregulin family. Its level is greater in PCOS than in control women, and Neuregulin-4 is linked to body fat percentage and liver fat, as well as insulin resistance (IR). Objectives: To estimate the serum NRG-4 levels in women diagnosed with (PCOS), to compare it with, non-PCOS healthy control and to explore the effect of hyperandrogenism on the obtained result. Patients and Methods: A case-control study was conducted in the Gynecology and the Infertility Clinics in Kut - Zahraa Hospital, Medical City, from September to December 2022. The study included 120 women aged (18-42) years, 60 of whom were diagnosed with polycystic ovaries, and the other 60 were in the control group. Results: Women with PCOS had a significantly higher NRG-4, LH, LH/FSH ratio, testosterone, free testosterone, and Dehydroepiandrosterone sulfate (DHEA-S) than the control groups. In this study, NRG-4 was significantly higher in obese and overweight PCOS women than in normal-weight women. Conclusion: The mean serum NGR-4 concentration is significantly increased in women with PCOS and could be a part of metabolic syndrome. NGR-4 levels were associated with obesity, hyperandrogenism (testosterone, free testosterone, and DHAES) and may have a role in the development of PCOS. Received: May,, 2022 Accepted: Oct, 2023 Published: Jan.2024 |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0041-9419 2410-8057 |
| Relation: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2140; https://doaj.org/toc/0041-9419; https://doaj.org/toc/2410-8057 |
| DOI: | 10.32007/jfacmedbagdad.2140 |
| Access URL: | https://doaj.org/article/a097f4ec3cc74f3baab0dfa028545378 |
| Accession Number: | edsdoj.097f4ec3cc74f3baab0dfa028545378 |
| Database: | Directory of Open Access Journals |
| ISSN: | 00419419 24108057 |
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| DOI: | 10.32007/jfacmedbagdad.2140 |
| Published in: | مجلة كلية الطب |
| Language: | English |