Academic Journal
Dataset on characterisation and stability of gingival retraction cord lignocaine–adrenaline nanogel optimised using central composite designMendeley Data
| Title: | Dataset on characterisation and stability of gingival retraction cord lignocaine–adrenaline nanogel optimised using central composite designMendeley Data |
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| Authors: | Min Mardhiyyah Azman, Muhammad Salahuddin Haris, Widya Lestari, Juzaily Husain, Omar Abdul Jabbar Abdul Qader, Wan Nor Hayati Wan Abd. Manan |
| Source: | Data in Brief, Vol 57, Iss , Pp 111028- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Computer applications to medicine. Medical informatics LCC:Science (General) |
| Subject Terms: | Lignocaine, Adrenaline, Nanotechnology, Central composite design, Haemostasis, Characterisation, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390 |
| More Details: | This study aims to characterise and assess the stability of an optimised lignocaine–adrenaline nanogel using central composite design (CCD). Compatibility studies were conducted using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) and Ultraviolet–visible (UV–vis) spectroscopy. Eighteen lignocaine–adrenaline Nanoemulsion (LANE) formulations derived using CCD were characterised for particle size, polydispersity index (PDI), zeta potential and pH. All LANE formulations were transformed into lignocaine-adrenaline Nanoemulsion-based Gel (NBG) by adding 0.1 % Carbopol 940. Stability studies for LANE and NBG were conducted for 12 months storage at 25 °C. The results of long-term stability assessment of LANEs and NBGs were integrated with CCD predictions to produce the optimised NBG, lignocaine–adrenaline Nanogel. The optimised NBG model was validated in triplicates. The optimised NBG was subjected to 5000 rpm centrifugation for 30 min, repeated heating-cooling cycles (40 °C and 4 °C), and a freeze-thaw cycle (-5 °C and 25 °C). ATR-FTIR and UV–vis results indicated compatibility between lignocaine, adrenaline and the excipients. The viscosity of the nanogel corresponded to that of ferric sulphate solution (24 ± 1 mPa·s at 20 °C). The LANE and NBG formulations showed no drug precipitation or phase separation after the stability study. The optimised NBG had particle size (61.76 ± 0.25 nm), PDI (0.36 ± 0.01), zeta potential (−26.47 ± 0.02 mV) and pH (6.28 ± 0.02). The optimised NBG remained stable in stress-induced environments. CCD enabled optimisation of a stable NBG formulation. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3409 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352340924009909; https://doaj.org/toc/2352-3409 |
| DOI: | 10.1016/j.dib.2024.111028 |
| Access URL: | https://doaj.org/article/c092e5ac50b946c49cfdfd9b5371439a |
| Accession Number: | edsdoj.092e5ac50b946c49cfdfd9b5371439a |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523409 |
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| DOI: | 10.1016/j.dib.2024.111028 |
| Published in: | Data in Brief |
| Language: | English |