Bibliographic Details
| Title: |
Systemic Tumors Can Cause Molecular Changes in the Hippocampus That May Have an Impact on Behavior after Chronic Social Stress |
| Authors: |
Olatz Goñi-Balentziaga, Alina Díez-Solinska, Garikoitz Beitia-Oyarzabal, Maider Muñoz-Culla, Garikoitz Azkona, Oscar Vegas |
| Source: |
NeuroSci, Vol 5, Iss 2, Pp 192-200 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
chronic social stress, monoamines, kynurenine pathway, tumor development, hippocampus, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Evidence indicates that chronic social stress plays a significant role in the development of cancer and depression. Although their association is recognized, the precise physiological mechanism remains unknown. In our previous work, we observed that OF1 males subjected to chronic social defiance exhibited anhedonia, and those who developed tumors in the lung showed anxiety-associated behaviors. In this study, we observed that tumor-bearing OF1 mice presented higher levels of 3-HK, and this increase may be due to IDO. No differences in hippocampal catecholamine levels were observed. Our results suggest that a systemic tumor can induce molecular changes in the hippocampal kynurenine pathway that may impact behavior. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-4087 |
| Relation: |
https://www.mdpi.com/2673-4087/5/2/14; https://doaj.org/toc/2673-4087 |
| DOI: |
10.3390/neurosci5020014 |
| Access URL: |
https://doaj.org/article/e092dd7207fc4554b5f11306e112d16b |
| Accession Number: |
edsdoj.092dd7207fc4554b5f11306e112d16b |
| Database: |
Directory of Open Access Journals |
