Bibliographic Details
| Title: |
Trends in SARS-CoV-2 seroprevalence among pregnant women attending first antenatal care visits in Zambia: A repeated cross-sectional survey, 2021-2022. |
| Authors: |
Elizabeth Heilmann, Tannia Tembo, Sombo Fwoloshi, Bupe Kabamba, Felix Chilambe, Kalubi Kalenga, Mpanji Siwingwa, Conceptor Mulube, Victoria Seffren, Carolyn Bolton-Moore, John Simwanza, Samuel Yingst, Ruchi Yadav, Eric Rogier, Andrew F Auld, Simon Agolory, Muzala Kapina, Julie R Gutman, Theodora Savory, Chabu Kangale, Lloyd B Mulenga, Izukanji Sikazwe, Jonas Z Hines |
| Source: |
PLOS Global Public Health, Vol 4, Iss 4, p e0003073 (2024) |
| Publisher Information: |
Public Library of Science (PLoS), 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Public aspects of medicine |
| Subject Terms: |
Public aspects of medicine, RA1-1270 |
| More Details: |
SARS-CoV-2 serosurveys help estimate the extent of transmission and guide the allocation of COVID-19 vaccines. We measured SARS-CoV-2 seroprevalence among women attending ANC clinics to assess exposure trends over time in Zambia. We conducted repeated cross-sectional SARS-CoV-2 seroprevalence surveys among pregnant women aged 15-49 years attending their first ANC visits in four districts of Zambia (two urban and two rural) during September 2021-September 2022. Serologic testing was done using a multiplex bead assay which detects IgG antibodies to the nucleocapsid protein and the spike protein receptor-binding domain (RBD). We calculated monthly SARS-CoV-2 seroprevalence by district. We also categorized seropositive results as infection alone, infection and vaccination, or vaccination alone based on anti-RBD and anti-nucleocapsid test results and self-reported COVID-19 vaccination status (vaccinated was having received ≥1 dose). Among 8,304 participants, 5,296 (63.8%) were cumulatively seropositive for SARS-CoV-2 antibodies from September 2021 through September 2022. SARS-CoV-2 seroprevalence primarily increased from September 2021 to September 2022 in three districts (Lusaka: 61.8-100.0%, Chongwe: 39.6-94.7%, Chipata: 56.5-95.0%), but in Chadiza, seroprevalence increased from 27.8% in September 2021 to 77.2% in April 2022 before gradually dropping to 56.6% in July 2022. Among 5,906 participants with a valid COVID-19 vaccination status, infection alone accounted for antibody responses in 77.7% (4,590) of participants. Most women attending ANC had evidence of prior SARS-CoV-2 infection and most SARS-CoV-2 seropositivity was infection-induced. Capturing COVID-19 vaccination status and using a multiplex bead assay with anti-nucleocapsid and anti-RBD targets facilitated distinguishing infection-induced versus vaccine-induced antibody responses during a period of increasing COVID-19 vaccine coverage in Zambia. Declining seroprevalence in Chadiza may indicate waning antibodies and a need for booster vaccines. ANC clinics have a potential role in ongoing SARS-CoV-2 serosurveillance and can continue to provide insights into SARS-CoV-2 antibody dynamics to inform near real-time public health responses. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2767-3375 |
| Relation: |
https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0003073&type=printable; https://doaj.org/toc/2767-3375 |
| DOI: |
10.1371/journal.pgph.0003073&type=printable |
| DOI: |
10.1371/journal.pgph.0003073 |
| Access URL: |
https://doaj.org/article/08ed2d9d75f244e2a97a42735265939e |
| Accession Number: |
edsdoj.08ed2d9d75f244e2a97a42735265939e |
| Database: |
Directory of Open Access Journals |
