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Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work – the HORMONIT study

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Title: Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work – the HORMONIT study
Authors: Barbara N Harding, Gemma Castaño-Vinyals, Anna Palomar-Cros, Kyriaki Papantoniou, Ana Espinosa, Debra J Skene, Benita Middleton, Alex Gomez-Gomez, José Maria Navarrete, Patricia Such Faro, Antonio Torrejón, Manolis Kogevinas, Oscar J Pozo
Source: Scandinavian Journal of Work, Environment & Health, Vol 48, Iss 1, Pp 41-51 (2022)
Publisher Information: Nordic Association of Occupational Safety and Health (NOROSH), 2022.
Publication Year: 2022
Collection: LCC:Public aspects of medicine
Subject Terms: melatonin, hormone, sex steroid, hormone production, hormonit, shift work, night work, circadian, rotating shift work, shift worker, Public aspects of medicine, RA1-1270
More Details: OBJECTIVE: Data from real world settings on circadian disruption and subsequent hormone-related changes may explain the higher risk of hormone-dependent cancers among night shift workers.The present study examines the melatonin and sex steroid hormone levels among night shift workers. METHODS: We included 44 male, rotating shift workers from a car factory in Spain, sampled both at the end of a 3-week night shift (22:00–06:00 hrs) and a 3-week early morning shift (06:00–14:00 hrs). Participants collected all urine voids over 24-hours during each shift. Urinary concentrations of sex steroid hormones (estrogens, androgens and progestogens) and 6-sulfatoxymelatonin (aMT6s, major melatonin metabolite) were determined. Individual cosinor analysis was used to derive the acrophase (peak time) and area under the curve (total production). Linear mixed models examined intraindividual associations between night shift work and log-transformed 24-hour peak time and total production of hormones compared to early morning shift work. RESULTS: The acrophase was delayed during the night shift for aMT6s [geometric mean difference (GMD) 7.53 hrs, 95% confidence interval (CI) 4.46–10.60], androgens (eg, testosterone: GMD 6.83 hrs, 95% CI 0.34–13.32) and progestogens (eg, 17-hydroxyprogesterone: GMD 4.54 hrs, 95% CI 2.92–6.16) compared to the early morning shift. We found a higher production of adrenal androgen 11-oxoandrosterone/11-oxoetiocholanolone [geometric mean ratio (GMR) 1.43, 95% CI 1.12–1.81], and a lower production of adrenal progestogen 16-cysteinylprogesterone (GMR 0.79, 95% CI 0.67–0.93) during the night shift compared to the early morning shift levels. CONCLUSIONS: Night shift work was associated with melatonin and sex hormone-related changes in timing and total production, providing insight into the mechanistic path for its association with hormone-dependent cancer.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 0355-3140
1795-990X
Relation: https://www.sjweh.fi/show_abstract.php?abstract_id=3991; https://doaj.org/toc/0355-3140; https://doaj.org/toc/1795-990X
DOI: 10.5271/sjweh.3991
Access URL: https://doaj.org/article/c08de61c09d74e5e9302746eaf2b4121
Accession Number: edsdoj.08de61c09d74e5e9302746eaf2b4121
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  Data: Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work – the HORMONIT study
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  Data: <searchLink fieldCode="AR" term="%22Barbara+N+Harding%22">Barbara N Harding</searchLink><br /><searchLink fieldCode="AR" term="%22Gemma+Castaño-Vinyals%22">Gemma Castaño-Vinyals</searchLink><br /><searchLink fieldCode="AR" term="%22Anna+Palomar-Cros%22">Anna Palomar-Cros</searchLink><br /><searchLink fieldCode="AR" term="%22Kyriaki+Papantoniou%22">Kyriaki Papantoniou</searchLink><br /><searchLink fieldCode="AR" term="%22Ana+Espinosa%22">Ana Espinosa</searchLink><br /><searchLink fieldCode="AR" term="%22Debra+J+Skene%22">Debra J Skene</searchLink><br /><searchLink fieldCode="AR" term="%22Benita+Middleton%22">Benita Middleton</searchLink><br /><searchLink fieldCode="AR" term="%22Alex+Gomez-Gomez%22">Alex Gomez-Gomez</searchLink><br /><searchLink fieldCode="AR" term="%22José+Maria+Navarrete%22">José Maria Navarrete</searchLink><br /><searchLink fieldCode="AR" term="%22Patricia+Such+Faro%22">Patricia Such Faro</searchLink><br /><searchLink fieldCode="AR" term="%22Antonio+Torrejón%22">Antonio Torrejón</searchLink><br /><searchLink fieldCode="AR" term="%22Manolis+Kogevinas%22">Manolis Kogevinas</searchLink><br /><searchLink fieldCode="AR" term="%22Oscar+J+Pozo%22">Oscar J Pozo</searchLink>
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  Data: Scandinavian Journal of Work, Environment & Health, Vol 48, Iss 1, Pp 41-51 (2022)
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  Data: <searchLink fieldCode="DE" term="%22melatonin%22">melatonin</searchLink><br /><searchLink fieldCode="DE" term="%22hormone%22">hormone</searchLink><br /><searchLink fieldCode="DE" term="%22sex+steroid%22">sex steroid</searchLink><br /><searchLink fieldCode="DE" term="%22hormone+production%22">hormone production</searchLink><br /><searchLink fieldCode="DE" term="%22hormonit%22">hormonit</searchLink><br /><searchLink fieldCode="DE" term="%22shift+work%22">shift work</searchLink><br /><searchLink fieldCode="DE" term="%22night+work%22">night work</searchLink><br /><searchLink fieldCode="DE" term="%22circadian%22">circadian</searchLink><br /><searchLink fieldCode="DE" term="%22rotating+shift+work%22">rotating shift work</searchLink><br /><searchLink fieldCode="DE" term="%22shift+worker%22">shift worker</searchLink><br /><searchLink fieldCode="DE" term="%22Public+aspects+of+medicine%22">Public aspects of medicine</searchLink><br /><searchLink fieldCode="DE" term="%22RA1-1270%22">RA1-1270</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: OBJECTIVE: Data from real world settings on circadian disruption and subsequent hormone-related changes may explain the higher risk of hormone-dependent cancers among night shift workers.The present study examines the melatonin and sex steroid hormone levels among night shift workers. METHODS: We included 44 male, rotating shift workers from a car factory in Spain, sampled both at the end of a 3-week night shift (22:00–06:00 hrs) and a 3-week early morning shift (06:00–14:00 hrs). Participants collected all urine voids over 24-hours during each shift. Urinary concentrations of sex steroid hormones (estrogens, androgens and progestogens) and 6-sulfatoxymelatonin (aMT6s, major melatonin metabolite) were determined. Individual cosinor analysis was used to derive the acrophase (peak time) and area under the curve (total production). Linear mixed models examined intraindividual associations between night shift work and log-transformed 24-hour peak time and total production of hormones compared to early morning shift work. RESULTS: The acrophase was delayed during the night shift for aMT6s [geometric mean difference (GMD) 7.53 hrs, 95% confidence interval (CI) 4.46–10.60], androgens (eg, testosterone: GMD 6.83 hrs, 95% CI 0.34–13.32) and progestogens (eg, 17-hydroxyprogesterone: GMD 4.54 hrs, 95% CI 2.92–6.16) compared to the early morning shift. We found a higher production of adrenal androgen 11-oxoandrosterone/11-oxoetiocholanolone [geometric mean ratio (GMR) 1.43, 95% CI 1.12–1.81], and a lower production of adrenal progestogen 16-cysteinylprogesterone (GMR 0.79, 95% CI 0.67–0.93) during the night shift compared to the early morning shift levels. CONCLUSIONS: Night shift work was associated with melatonin and sex hormone-related changes in timing and total production, providing insight into the mechanistic path for its association with hormone-dependent cancer.
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  Data: https://www.sjweh.fi/show_abstract.php?abstract_id=3991; https://doaj.org/toc/0355-3140; https://doaj.org/toc/1795-990X
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        Value: 10.5271/sjweh.3991
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        Type: general
      – SubjectFull: hormone
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      – SubjectFull: sex steroid
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      – SubjectFull: circadian
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