| Title: |
Risk stratification for early mortality in newly diagnosed acute promyelocytic leukemia: a multicenter, non-selected, retrospective cohort study |
| Authors: |
Suhyeon Kim, Jiye Jung, Seo-Yeon Ahn, Mihee Kim, So Yeon Jeon, Chang-Hoon Lee, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Byung-Soo Kim, Hyeoung-Joon Kim, Jae-Yong Kwak, Yong Park, Jae-Sook Ahn, Ho-Young Yhim |
| Source: |
Frontiers in Oncology, Vol 14 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
acute promyelocytic leukemia, all-trans retinoic acid, early mortality, prognosis, risk stratification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
IntroductionDespite the current effective treatments for acute promyelocytic leukemia (APL), early mortality (EM), defined as death within 30 days of presentation, is a major hurdle to long-term survival.MethodsWe performed a multicenter retrospective study to evaluate the incidence and clinical characteristics of EM in patients with newly diagnosed APL and to develop a risk stratification model to predict EM.ResultsWe identified 313 eligible patients diagnosed between 2000 and 2021 from five academic hospitals. The median age was 50 years (range 19-94), and 250 (79.9%) patients were 24 hours of presentation (HR, 2.95). Based on these factors, patients were stratified into three categories with a significantly increasing risk of EM: 4.1% for low risk (54.3%; no risk factors; HR 1), 18.5% for intermediate risk (34.5%; 1 factor; HR 4.81), and 40.5% for high risk (11.2%; 2-3 factors; HR 13.16).DiscussionThe risk of EM is still not negligible in this era of ATRA-based therapies. Our risk model serves as a clinically useful tool to identify high-risk patients for EM who may be candidates for novel treatments and aggressive supportive strategies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2024.1307315/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2024.1307315 |
| Access URL: |
https://doaj.org/article/08d6174f21f24c38aeeff570d43c37d0 |
| Accession Number: |
edsdoj.08d6174f21f24c38aeeff570d43c37d0 |
| Database: |
Directory of Open Access Journals |
