Academic Journal
Self-assembled carbon monoxide nanogenerators managing sepsis through scavenging multiple inflammatory mediators
| Title: | Self-assembled carbon monoxide nanogenerators managing sepsis through scavenging multiple inflammatory mediators |
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| Authors: | Yang Wu, Xia Chen, Zhaolin Zeng, Bei Chen, Zhenxing Wang, Zhiyong Song, Hui Xie |
| Source: | Bioactive Materials, Vol 39, Iss , Pp 595-611 (2024) |
| Publisher Information: | KeAi Communications Co., Ltd., 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| Subject Terms: | Sepsis, Carbon monoxide nanogenerator, Heme oxygenase-1, Scavenging inflammatory storm, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| More Details: | Sepsis, a life-threatening syndrome of organ damage resulting from dysregulated inflammatory response, is distinguished by overexpression of inflammatory cytokines, excessive generation of reactive oxygen/nitrogen species (RONS), heightened activation of pyroptosis, and suppression of autophagy. However, current clinical symptomatic supportive treatment has failed to reduce the high mortality. Herein, we developed self-assembled multifunctional carbon monoxide nanogenerators (Nano CO), as sepsis drug candidates, which can release CO in response to ROS, resulting in clearing bacteria and activating the heme oxygenase-1/CO system. This activation strengthened endogenous protection and scavenged multiple inflammatory mediators to alleviate the cytokine storm, including scavenging RONS and cfDNA, inhibiting macrophage activation, blocking pyroptosis and activating autophagy. Animal experiments show that Nano CO has a good therapeutic effect on mice with LPS-induced sepsis, which is manifested in hypothermia recovery, organ damage repair, and a 50% decrease in mortality rates. Taken together, these results illustrated the efficacy of multifunctional Nano CO to target clearance of multiple mediators in sepsis treatment and act against other refractory inflammation-related diseases. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X24001440; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2024.04.013 |
| Access URL: | https://doaj.org/article/0853b7c7b663408ebae1cbe4b0be3611 |
| Accession Number: | edsdoj.0853b7c7b663408ebae1cbe4b0be3611 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2024.04.013 |
| Published in: | Bioactive Materials |
| Language: | English |