Bibliographic Details
| Title: |
Androgen Receptor mRNA Expression in Urothelial Carcinoma of the Bladder: A Retrospective Analysis of Two Independent Cohorts |
| Authors: |
Danijel Sikic, Ralph M. Wirtz, Sven Wach, Lars Dyrskjøt, Philipp Erben, Christian Bolenz, Johannes Breyer, Wolfgang Otto, Katherine A. Hoadley, Seth P. Lerner, Markus Eckstein, Arndt Hartmann, Bastian Keck |
| Source: |
Translational Oncology, Vol 12, Iss 4, Pp 661-668 (2019) |
| Publisher Information: |
Elsevier, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
INTRODUCTION: Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS: The association of AR mRNA expression with clinicopathological features was retrospectively analyzed in two previously described cohorts. The first cohort consisted of 41 patients with all stages of UCB treated at Aarhus University Hospital, Denmark. The second cohort consisted of 323 patients with muscle-invasive bladder cancer (MIBC) accumulated by the Cancer Genome Atlas (TCGA) Research Network. RESULTS: AR mRNA expression is significantly higher in non-muscle-invasive bladder cancer (NMIBC) when compared to MIBC (P = .0004), with no relevant changes within the different stages of MIBC. AR mRNA expression was significantly associated with TCGA molecular subtypes (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1936-5233 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1936523318306478; https://doaj.org/toc/1936-5233 |
| DOI: |
10.1016/j.tranon.2019.01.005 |
| Access URL: |
https://doaj.org/article/07ed23158aca44659eca38a9a94652e4 |
| Accession Number: |
edsdoj.07ed23158aca44659eca38a9a94652e4 |
| Database: |
Directory of Open Access Journals |
