Bibliographic Details
| Title: |
Coronary CTA-based radiomic signature of pericoronary adipose tissue predict rapid plaque progression |
| Authors: |
Yue Li, Huaibi Huo, Hui Liu, Yue Zheng, Zhaoxin Tian, Xue Jiang, Shiqi Jin, Yang Hou, Qi Yang, Fei Teng, Ting Liu |
| Source: |
Insights into Imaging, Vol 15, Iss 1, Pp 1-12 (2024) |
| Publisher Information: |
SpringerOpen, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medical physics. Medical radiology. Nuclear medicine |
| Subject Terms: |
Radiomic analysis, Rapid plaque progression, Coronary computed tomography angiography, Pericoronary adipose tissue, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| More Details: |
Abstract Objectives To explore the value of radiomic features derived from pericoronary adipose tissue (PCAT) obtained by coronary computed tomography angiography for prediction of coronary rapid plaque progression (RPP). Methods A total of 1233 patients from two centers were included in this multicenter retrospective study. The participants were divided into training, internal validation, and external validation cohorts. Conventional plaque characteristics and radiomic features of PCAT were extracted and analyzed. Random Forest was used to construct five models. Model 1: clinical model. Model 2: plaque characteristics model. Model 3: PCAT radiomics model. Model 4: clinical + radiomics model. Model 5: plaque characteristics + radiomics model. The evaluation of the models encompassed identification accuracy, calibration precision, and clinical applicability. Delong’ test was employed to compare the area under the curve (AUC) of different models. Results Seven radiomic features, including two shape features, three first-order features, and two textural features, were selected to build the PCAT radiomics model. In contrast to the clinical model and plaque characteristics model, the PCAT radiomics model (AUC 0.85 for training, 0.84 for internal validation, and 0.81 for external validation; p 0.05). Conclusion Radiomic feature analysis derived from PCAT significantly improves the prediction of RPP as compared to clinical and plaque characteristics. Radiomic analysis of PCAT may improve monitoring RPP over time. Critical relevance statement Our findings demonstrate PCAT radiomics model exhibited good performance in the prediction of RPP, with potential clinical value. Key Points Rapid plaque progression may be predictable with radiomics from pericoronary adipose tissue. Fibrous plaque volume, diameter stenosis, and fat attenuation index were identified as risk factors for predicting rapid plaque progression. Radiomics features of pericoronary adipose tissue can improve the predictive ability of rapid plaque progression. Graphical Abstract |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1869-4101 |
| Relation: |
https://doaj.org/toc/1869-4101 |
| DOI: |
10.1186/s13244-024-01731-7 |
| Access URL: |
https://doaj.org/article/a07792f16eb24e16bd5404ea689ef02b |
| Accession Number: |
edsdoj.07792f16eb24e16bd5404ea689ef02b |
| Database: |
Directory of Open Access Journals |
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