Bibliographic Details
| Title: |
Pharmacokinetic/pharmacodynamic evaluation of teicoplanin against Staphylococcus aureus in a murine thigh infection model |
| Authors: |
Erika Watanabe, Kazuaki Matsumoto, Kazuro Ikawa, Yuta Yokoyama, Akari Shigemi, Yuki Enoki, Yasuhiro Umezaki, Koyo Nakamura, Keiichiro Ueno, Hideyuki Terazono, Norifumi Morikawa, Yasuo Takeda |
| Source: |
Journal of Global Antimicrobial Resistance, Vol 24, Iss , Pp 83-87 (2021) |
| Publisher Information: |
Elsevier, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
Teicoplanin, Methicillin-resistant Staphylococcus aureus, Methicillin-susceptible Staphylococcus aureus, Pharmacokinetics/pharmacodynamics, Neutropenic murine thigh infection model, Microbiology, QR1-502 |
| More Details: |
Objectives: Pharmacokinetic/pharmacodynamic (PK/PD) analysis using murine infection models is a well-established methodology for optimising antimicrobial therapy. Therefore, we investigated the PK/PD indices of teicoplanin againstStaphylococcus aureus using a murine thigh infection model. Methods: Mice were rendered neutropenic by administration of a two-step dosing of cyclophosphamide. Then, isolates of methicillin-susceptibleS. aureus (MSSA) or methicillin-resistant S. aureus (MRSA) were inoculated into the thighs of neutropenic mice. PK/PD analyses were performed by non-linear least-squared regression using the MULTI program. Results: Target values offCmax/MIC (r2 = 0.94) of teicoplanin for static effect and 1 log10 kill against MSSA were 4.44 and 15.44, respectively. Target values of fAUC24/MIC (r2 = 0.92) of teicoplanin for static effect and 1 log10 kill against MSSA were 30.4 and 70.56, respectively. Target values of fCmax/MIC (r2 = 0.91) of teicoplanin for static effect and 1 log10 kill against MRSA were 8.92 and 14.16, respectively. Target values of fAUC24/MIC (r2 = 0.92) of teicoplanin for static effect and 1 log10 kill against MRSA were 54.8 and 76.4, respectively. Conclusion: These results suggest thatfCmax/MIC and fAUC24/MIC are useful PK/PD indices of teicoplanin against MSSA and MRSA. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2213-7165 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2213716520303003; https://doaj.org/toc/2213-7165 |
| DOI: |
10.1016/j.jgar.2020.11.014 |
| Access URL: |
https://doaj.org/article/074a031110824a18ab1ea363f3b857a3 |
| Accession Number: |
edsdoj.074a031110824a18ab1ea363f3b857a3 |
| Database: |
Directory of Open Access Journals |
