The nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance
| Title: | The nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance |
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| Authors: | Ryan M. Gill, Daniela Allende, Patricia H. Belt, Cynthia A. Behling, Oscar W. Cummings, Cynthia D. Guy, Daniela Carpenter, Brent A. Neuschwander-Tetri, Arun J. Sanyal, James Tonascia, Mark L. Van Natta, Laura A. Wilson, Goro Yamada, Matthew Yeh, David E. Kleiner, for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) |
| Source: | Hepatology Communications, Vol 7, Iss 2, Pp e0033-e0033 (2023) |
| Publisher Information: | Wolters Kluwer Health/LWW, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | Background and Aims:. The NAFLD activity score was developed to measure histologic changes in NAFLD during therapeutic trials. Hepatocyte ballooning (HB) is the most specific feature in steatohepatitis diagnosis, yet the impact of variations in HB has not been incorporated. Approach and Results:. Liver biopsies from patients enrolled in the NASH Clinical Research Network with an initial diagnosis of NASH or NAFL (n=1688) were evaluated to distinguish classic hepatocyte ballooning (cHB) from smaller, nonclassic hepatocyte ballooning (nHB), and also to designate severe ballooning and assign an extended hepatocyte ballooning (eB) score [0 points, no ballooning (NB); 1 point, few or many nHB; 2 points, few cHB; 3 points, many cHB; 4 points, severe cHB] to the biopsy assessment. The eB score was reproducible among NASH CRN liver pathologists (weighted kappa 0.76) and was significantly associated with older age (mean 52.1 y, cHB; 48.5 y, nHB, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2471-254X 00000000 |
| Relation: | http://journals.lww.com/10.1097/HC9.0000000000000033; https://doaj.org/toc/2471-254X |
| DOI: | 10.1097/HC9.0000000000000033 |
| Access URL: | https://doaj.org/article/e064dc2fe4194521b39689b3632131c5 |
| Accession Number: | edsdoj.064dc2fe4194521b39689b3632131c5 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2471254X 00000000 |
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| DOI: | 10.1097/HC9.0000000000000033 |
| Published in: | Hepatology Communications |
| Language: | English |