Bibliographic Details
| Title: |
Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells |
| Authors: |
María-Carmen López de las Hazas, Joana Godinho-Pereira, Alba Macià, A. Filipa Almeida, M. Rita Ventura, Maria-José Motilva, Cláudia N. Santos |
| Source: |
Journal of Functional Foods, Vol 46, Iss , Pp 110-117 (2018) |
| Publisher Information: |
Elsevier, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
Bioactivity, Dopaminergic cells, Hydroxytyrosol, Neurodegeneration, Phase-II metabolites, Sulphation, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
Hydroxytyrosol (HT) and oleuropein derivatives are the main phenolic compounds in virgin olive oil (VOO). After VOO intake, HT is extensively metabolized being hydroxytyrosol-sulphate (HT-S) and hydroxytyrosol-acetate sulphate (HT-AC-S) the main circulating metabolites detected in human plasma. The brain uptake and accumulation of HT and its metabolites were observed after 21 days of rat diet supplementation (5 mg/kg rat/day) of HT in its native form or through oleuropein derivatives. To establish their neuroprotective potential HT-S and HT-AC-S were chemically synthetized and their protective effects against oxidative stress at physiological concentrations (10 μM) in neuroblastoma (SH-SY5Y) and dopaminergic (LUHMES) neuronal cells were observed. The sulpho-conjugated HT structures showed a lower protective effect than native HT. Results showed brain accumulation of HT and HT-S, suggesting their neuroprotective activity by the reduction of the oxidative stress at neuronal level. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464618301671; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2018.04.028 |
| Access URL: |
https://doaj.org/article/061f8853a1c9436492135d3232cb78e1 |
| Accession Number: |
edsdoj.061f8853a1c9436492135d3232cb78e1 |
| Database: |
Directory of Open Access Journals |
