Bibliographic Details
| Title: |
Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer |
| Authors: |
Lorenz Frehner, Simon Haefliger, Ferdinando Cerciello, Tobias Grob, Sabine Schmid |
| Source: |
Case Reports in Oncology, Vol 16, Iss 1, Pp 871-877 (2023) |
| Publisher Information: |
Karger Publishers, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
targeted therapy, ntrk2, non-small cell lung cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of these agents in patients with NSCLC and NTRK2 fusion are available. We present a case of a female patient with NTRK2-positive NSCLC with a complete ongoing response on therapy with larotrectinib, suggesting efficacy of first-generation TRK inhibitors also in NTRK2-positive NSCLC. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1662-6575 |
| Relation: |
https://beta.karger.com/Article/FullText/533572; https://doaj.org/toc/1662-6575 |
| DOI: |
10.1159/000533572 |
| Access URL: |
https://doaj.org/article/057b934bc8824803a930934fdce6200c |
| Accession Number: |
edsdoj.057b934bc8824803a930934fdce6200c |
| Database: |
Directory of Open Access Journals |
