Bibliographic Details
| Title: |
The kinetics of the reduction of the lipophilic quinone avarone by n-alkyl-1,4-dihydronicotinamides of various lipophilicities |
| Authors: |
MIROSLAV J. GASIC, DUSAN SLADIC, MARIO ZLATOVIC |
| Source: |
Journal of the Serbian Chemical Society, Vol 64, Iss 11, Pp 647-654 (1999) |
| Publisher Information: |
Serbian Chemical Society, 1999. |
| Publication Year: |
1999 |
| Collection: |
LCC:Chemistry |
| Subject Terms: |
avarone, quinone, NADH models, surfactants, kinetics, Chemistry, QD1-999 |
| More Details: |
Several NADH model compounds, N-alkyl-1,4-dihydronicotinamides, some of them possessing amphiphilic properties, have been synthesized, and the kinetics of their reaction with a biologically active liphophilic quinone, avarone, has been studied in a protic solvent both in the presence and absence of cationic, anionic or non-ionic surfactants. In the absence of micellar agents, the medium- and long-chain N-dodecyl (3) and N-heptadecyl (4) derivatives show a significant increase in the reaction rates compared to other model compounds, due to the stabilization of the semiquinone intermediate. Anionic surfactants retard the reaction, non-ionic surfactants slightly accelerate the reaction with the short-chain derivatives, and retard the reaction with the medium- and long-chain derivatives, and the cationic surfactants increase the reaction rate with all derivatives except the long-chain 4. The results support the e-p-e mechanism of the reduction of lipophilic quinones by NADH models in protic medium. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
0352-5139 |
| Relation: |
http://www.shd.org.yu/HtDocs/SHD/Vol64/No11-Pdf/V64-no11-01.zip; https://doaj.org/toc/0352-5139 |
| Access URL: |
https://doaj.org/article/aa0551600b554571a89aff7b45b9b63f |
| Accession Number: |
edsdoj.0551600b554571a89aff7b45b9b63f |
| Database: |
Directory of Open Access Journals |
