Bibliographic Details
| Title: |
Evolution of trimethoprim/sulfamethoxazole resistance in Shewanella algae from the perspective of comparative genomics and global phylogenic analysis |
| Authors: |
Liu Chia-Wei, Jan-Fang Cheng, Kwong-Chung Tung, Yu-Kai Hong, Jyun-Hong Lin, Yu-Hui Lin, Che-An Tsai, Shih-Ping Lin, Yung-Chun Chen, Zhi-Yuan Shi, Yao-Ting Huang, Po-Yu Liu |
| Source: |
Journal of Microbiology, Immunology and Infection, Vol 55, Iss 6, Pp 1195-1202 (2022) |
| Publisher Information: |
Elsevier, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
Shewanella algae, Trimethoprim/sulfamethoxazole(TMP/SMX), sull, Class 1 integron, Microbiology, QR1-502 |
| More Details: |
Objective: Shewanella algae is a zoonotic marine bacterium that causes a variety of infections in immunocompromised patients or those who have been exposed to seawater. The development of trimethoprim/sulfamethoxazole (TMP/SMX) resistance in S. algae are found in human and environment isolates during the past ten years, and thus the treatment options are decreasing. Methodology: In the study, we conduct a comparative genomic study to identify the resistant mechanism of TMP/SMX-resistance in S. algae. Results: We found the resistance of TMP/SMX in S. algae is associated with the existence of sul1 and dfrA12 within the class 1 integron. The gene cassette dfra12-aadA2-qacEΔ1/sul1 within the class 1 integron is highly conserved. In addition, the class 1 integron and encapsulated sul1 are significantly enriched in Enterobacteriaceae in NCBI and UniProt databases. Conclusion: Our study suggests that the horizontal transfer of TMP/SMX resistance via class 1 integron is most frequently occurred within Enterobacteriaceae and has spread to a wide range of sources including soil, poultry, and marine water. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1684-1182 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1684118221002024; https://doaj.org/toc/1684-1182 |
| DOI: |
10.1016/j.jmii.2021.09.014 |
| Access URL: |
https://doaj.org/article/a054d974ab424d8c91e169d9416299de |
| Accession Number: |
edsdoj.054d974ab424d8c91e169d9416299de |
| Database: |
Directory of Open Access Journals |
