Academic Journal
View in EDS
Linked Full Text

A novel web-based online nomogram to predict advanced liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome

Bibliographic Details
Title: A novel web-based online nomogram to predict advanced liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome
Authors: Zhiyi Zhang, Jian Wang, Yun Chen, Yiguang Li, Li Zhu, Huali Wang, Yilin Liu, Jiacheng Liu, Shengxia Yin, Xin Tong, Xiaomin Yan, Yuxin Chen, Chuanwu Zhu, Jie Li, Yuanwang Qiu, Chao Wu, Rui Huang
Source: Journal of Translational Autoimmunity, Vol 7, Iss , Pp 100215- (2023)
Publisher Information: Elsevier, 2023.
Publication Year: 2023
Collection: LCC:Immunologic diseases. Allergy
Subject Terms: Autoimmune hepatitis, Primary biliary cholangitis, Overlap syndrome, Liver fibrosis, Nomogram, Biopsy, Immunologic diseases. Allergy, RC581-607
More Details: Background: Patients with autoimmune hepatitis-primary biliary cholangitis (AIH-PBC) overlap syndrome have a worse prognosis compared to AIH or PBC alone and accurately predicting the severity and dynamically monitoring the progression of disease are therefore essential. We aimed to develop a nomogram-based model to predict advanced liver fibrosis in patients with AIH-PBC overlap syndrome. Methods: A total of 121 patients with AIH-PBC overlap syndrome were retrospectively included and randomly assigned to a development set and a validation set. Backward stepwise regression's best model with the lowest AIC was employed to create a nomogram. Diagnose accuracy was evaluated using the area under the receiver operator characteristic curve (AUROC), calibration analysis, and decision curve analysis (DCA) and was compared with aspartate aminotransferase-to-platelet ratio (APRI) and fibrosis index based on four factors-4 (FIB-4) score. Results: The median age of patients was 53.0 years (IQR: 46.0–63.0), and female patients accounted for 95.0 %. Platelets, globulin, total bilirubin, and prothrombin time were associated with advanced fibrosis (≥S3) and used to construct an AIH-PBC overlap syndrome fibrosis (APOSF)-nomogram (available online at https://ndth-zzy.shinyapps.io/APOSF-nomogram/). The AUROCs of APOSF-nomogram were 0.845 (95 % CI: 0.754–0.936) and 0.843 (95 % CI: 0.705–0.982) in development set and validation set respectively, which was significantly better than APRI and FIB-4. Calibration revealed that the estimated risk fits well with biopsy-proven observation. DCA outperformed APRI and FIB4 in terms of net benefit, demonstrating clinical utility. Conclusion: This novel non-invasive web-based online APOSF-nomogram provided a convenient tool for identifying advanced fibrosis in patients with AIH-PBC overlap syndrome. Further prospective, multicenter studies with large sample size are necessary to validate the applicability of APOSF-nomogram.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2589-9090
Relation: http://www.sciencedirect.com/science/article/pii/S258990902300028X; https://doaj.org/toc/2589-9090
DOI: 10.1016/j.jtauto.2023.100215
Access URL: https://doaj.org/article/0529efbe94c64b52be5b68f27ecc2e3d
Accession Number: edsdoj.0529efbe94c64b52be5b68f27ecc2e3d
Database: Directory of Open Access Journals
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4B98983558C4D8F6DBD2&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.jtauto.2023.100215?
    Name: ScienceDirect (all content)-s8985755
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=25899090&ISBN=&volume=7&issue=100215-&date=20231201&spage=&pages=&title=Journal of Translational Autoimmunity&atitle=A%20novel%20web-based%20online%20nomogram%20to%20predict%20advanced%20liver%20fibrosis%20in%20patients%20with%20autoimmune%20hepatitis-primary%20biliary%20cholangitis%20overlap%20syndrome&aulast=Zhiyi%20Zhang&id=DOI:10.1016/j.jtauto.2023.100215
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/0529efbe94c64b52be5b68f27ecc2e3d
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.0529efbe94c64b52be5b68f27ecc2e3d
RelevancyScore: 983
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 983.169921875
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A novel web-based online nomogram to predict advanced liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zhiyi+Zhang%22">Zhiyi Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Jian+Wang%22">Jian Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Yun+Chen%22">Yun Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Yiguang+Li%22">Yiguang Li</searchLink><br /><searchLink fieldCode="AR" term="%22Li+Zhu%22">Li Zhu</searchLink><br /><searchLink fieldCode="AR" term="%22Huali+Wang%22">Huali Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Yilin+Liu%22">Yilin Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Jiacheng+Liu%22">Jiacheng Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Shengxia+Yin%22">Shengxia Yin</searchLink><br /><searchLink fieldCode="AR" term="%22Xin+Tong%22">Xin Tong</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaomin+Yan%22">Xiaomin Yan</searchLink><br /><searchLink fieldCode="AR" term="%22Yuxin+Chen%22">Yuxin Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Chuanwu+Zhu%22">Chuanwu Zhu</searchLink><br /><searchLink fieldCode="AR" term="%22Jie+Li%22">Jie Li</searchLink><br /><searchLink fieldCode="AR" term="%22Yuanwang+Qiu%22">Yuanwang Qiu</searchLink><br /><searchLink fieldCode="AR" term="%22Chao+Wu%22">Chao Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Rui+Huang%22">Rui Huang</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of Translational Autoimmunity, Vol 7, Iss , Pp 100215- (2023)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Elsevier, 2023.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2023
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Immunologic diseases. Allergy
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Autoimmune+hepatitis%22">Autoimmune hepatitis</searchLink><br /><searchLink fieldCode="DE" term="%22Primary+biliary+cholangitis%22">Primary biliary cholangitis</searchLink><br /><searchLink fieldCode="DE" term="%22Overlap+syndrome%22">Overlap syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+fibrosis%22">Liver fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Nomogram%22">Nomogram</searchLink><br /><searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%2E+Allergy%22">Immunologic diseases. Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22RC581-607%22">RC581-607</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Background: Patients with autoimmune hepatitis-primary biliary cholangitis (AIH-PBC) overlap syndrome have a worse prognosis compared to AIH or PBC alone and accurately predicting the severity and dynamically monitoring the progression of disease are therefore essential. We aimed to develop a nomogram-based model to predict advanced liver fibrosis in patients with AIH-PBC overlap syndrome. Methods: A total of 121 patients with AIH-PBC overlap syndrome were retrospectively included and randomly assigned to a development set and a validation set. Backward stepwise regression's best model with the lowest AIC was employed to create a nomogram. Diagnose accuracy was evaluated using the area under the receiver operator characteristic curve (AUROC), calibration analysis, and decision curve analysis (DCA) and was compared with aspartate aminotransferase-to-platelet ratio (APRI) and fibrosis index based on four factors-4 (FIB-4) score. Results: The median age of patients was 53.0 years (IQR: 46.0–63.0), and female patients accounted for 95.0 %. Platelets, globulin, total bilirubin, and prothrombin time were associated with advanced fibrosis (≥S3) and used to construct an AIH-PBC overlap syndrome fibrosis (APOSF)-nomogram (available online at https://ndth-zzy.shinyapps.io/APOSF-nomogram/). The AUROCs of APOSF-nomogram were 0.845 (95 % CI: 0.754–0.936) and 0.843 (95 % CI: 0.705–0.982) in development set and validation set respectively, which was significantly better than APRI and FIB-4. Calibration revealed that the estimated risk fits well with biopsy-proven observation. DCA outperformed APRI and FIB4 in terms of net benefit, demonstrating clinical utility. Conclusion: This novel non-invasive web-based online APOSF-nomogram provided a convenient tool for identifying advanced fibrosis in patients with AIH-PBC overlap syndrome. Further prospective, multicenter studies with large sample size are necessary to validate the applicability of APOSF-nomogram.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2589-9090
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://www.sciencedirect.com/science/article/pii/S258990902300028X; https://doaj.org/toc/2589-9090
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.jtauto.2023.100215
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/0529efbe94c64b52be5b68f27ecc2e3d" linkWindow="_blank">https://doaj.org/article/0529efbe94c64b52be5b68f27ecc2e3d</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.0529efbe94c64b52be5b68f27ecc2e3d
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.0529efbe94c64b52be5b68f27ecc2e3d
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jtauto.2023.100215
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Autoimmune hepatitis
        Type: general
      – SubjectFull: Primary biliary cholangitis
        Type: general
      – SubjectFull: Overlap syndrome
        Type: general
      – SubjectFull: Liver fibrosis
        Type: general
      – SubjectFull: Nomogram
        Type: general
      – SubjectFull: Biopsy
        Type: general
      – SubjectFull: Immunologic diseases. Allergy
        Type: general
      – SubjectFull: RC581-607
        Type: general
    Titles:
      – TitleFull: A novel web-based online nomogram to predict advanced liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhiyi Zhang
      – PersonEntity:
          Name:
            NameFull: Jian Wang
      – PersonEntity:
          Name:
            NameFull: Yun Chen
      – PersonEntity:
          Name:
            NameFull: Yiguang Li
      – PersonEntity:
          Name:
            NameFull: Li Zhu
      – PersonEntity:
          Name:
            NameFull: Huali Wang
      – PersonEntity:
          Name:
            NameFull: Yilin Liu
      – PersonEntity:
          Name:
            NameFull: Jiacheng Liu
      – PersonEntity:
          Name:
            NameFull: Shengxia Yin
      – PersonEntity:
          Name:
            NameFull: Xin Tong
      – PersonEntity:
          Name:
            NameFull: Xiaomin Yan
      – PersonEntity:
          Name:
            NameFull: Yuxin Chen
      – PersonEntity:
          Name:
            NameFull: Chuanwu Zhu
      – PersonEntity:
          Name:
            NameFull: Jie Li
      – PersonEntity:
          Name:
            NameFull: Yuanwang Qiu
      – PersonEntity:
          Name:
            NameFull: Chao Wu
      – PersonEntity:
          Name:
            NameFull: Rui Huang
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 25899090
          Numbering:
            – Type: volume
              Value: 7
            – Type: issue
              Value: 100215-
          Titles:
            – TitleFull: Journal of Translational Autoimmunity
              Type: main
ResultId 1