| Title: |
The Probiotic Kluyveromyces lactis JSA 18 Alleviates Obesity and Hyperlipidemia in High-Fat Diet C57BL/6J Mice |
| Authors: |
Yingxiang Hong, Guodong Song, Xiaoqian Feng, Jialei Niu, Lu Wang, Caini Yang, Xuegang Luo, Sa Zhou, Wenjian Ma |
| Source: |
Foods, Vol 13, Iss 7, p 1124 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Chemical technology |
| Subject Terms: |
obesity, Kluyveromyces lactis, Lactobacillus plantarum, gut microbiota, gut fungi, Chemical technology, TP1-1185 |
| More Details: |
Obesity poses a significant threat to various health conditions such as heart diseases, diabetes, high blood pressure, and heart attack, with the gut microbiota playing a crucial role in maintaining the body’s energy balance. We identified a novel probiotic fungal strain, Kluyveromyces lactis JSA 18 (K. lactis), which was isolated from yak milk and was found to possess anti-obesity properties. Additionally, Lactobacillus plantarum CGMCC 8198 (LP8198) from our previous study was also included to evaluate its anti-obesity properties. The findings indicated that K. lactis caused a notable reduction in weight gain, liver and fat indexes, and hyperlipidemia in mice fed a high-fat diet (HFD). Administering K. lactis and LP8198 to mice on a high-fat diet resulted in a reduction of serum triglyceride levels. Furthermore, the supplements reduced ALT and AST activity, and inhibited the production of inflammatory cytokines such as TNF-α and IL-1β. In addition, lipid metabolism was enhanced by the downregulation of ACC1, PPAR-γ, SREBP-1, and Fasn. Moreover, this study found that K. lactis and LP8198 have little effect on gut bacteria. Additionally, K. lactis partially influenced intestinal fungi, while LP8198 had a minor influence on gut mycobiota. The main goal of this research was to show how effective K. lactis can be as a probiotic in combating obesity. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2304-8158 |
| Relation: |
https://www.mdpi.com/2304-8158/13/7/1124; https://doaj.org/toc/2304-8158 |
| DOI: |
10.3390/foods13071124 |
| Access URL: |
https://doaj.org/article/04f3bf4a60b74d019600d817fb5bc59d |
| Accession Number: |
edsdoj.04f3bf4a60b74d019600d817fb5bc59d |
| Database: |
Directory of Open Access Journals |
