Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

Bibliographic Details
Title: Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
Authors: Luke C Pilling, Janice L Atkins, Michael O Duff, Robin N Beaumont, Samuel E Jones, Jessica Tyrrell, Chia-Ling Kuo, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Andrew R Wood, Anna Murray, Michael N Weedon, Lorna W Harries, George A Kuchel, Luigi Ferrucci, Timothy M Frayling, David Melzer
Source: PLoS ONE, Vol 12, Iss 9, p e0185083 (2017)
Publisher Information: Public Library of Science (PLoS), 2017.
Publication Year: 2017
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: Variability in red blood cell volumes (distribution width, RDW) increases with age and is strongly predictive of mortality, incident coronary heart disease and cancer. We investigated inherited genetic variation associated with RDW in 116,666 UK Biobank human volunteers.A large proportion RDW is explained by genetic variants (29%), especially in the older group (60+ year olds, 33.8%,
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1932-6203
Relation: http://europepmc.org/articles/PMC5619771?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0185083
Access URL: https://doaj.org/article/04a4afe477254fa0ac97b5879cde81ff
Accession Number: edsdoj.04a4afe477254fa0ac97b5879cde81ff
Database: Directory of Open Access Journals
More Details
ISSN:19326203
DOI:10.1371/journal.pone.0185083
Published in:PLoS ONE
Language:English