Comparison between single-agent chemotherapy in low-risk gestational trophoblastic neoplasia
| Title: | Comparison between single-agent chemotherapy in low-risk gestational trophoblastic neoplasia |
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| Authors: | Leila Mousavi Seresht, Marjaneh Farazestanian, Zohreh Yousefi |
| Source: | Caspian Journal of Internal Medicine, Vol 14, Iss 1, Pp 108-111 (2023) |
| Publisher Information: | Babol University of Medical Sciences, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Internal medicine |
| Subject Terms: | actinomycin, gestational trophoblastic neoplasia, methotrexate, outcome, single-agent chemotherapy., Internal medicine, RC31-1245 |
| More Details: | Background: Low-risk gestational trophoblastic neoplasia could be cured in the case of appropriate management with single-agent chemotherapy. This study was carried out to compare the efficacy of single-dose methotrexate versus Actinomycin-D in low-risk gestational trophoblastic neoplasia to analyze the most effective agent. Methods: This retrospective cohort study was conducted on the medical record of 170 cases with the diagnosis of low-risk gestational trophoblastic neoplasia from 2012 to 2019 to evaluate the response rate of single-dose weekly-methotrexate versus biweekly-Actinomycin-D. Results: Single agent chemotherapy was required in 170 patients with final risk score of less than 7. Among the 100 cases under weekly-methotrexate therapy, 29 patients were required second-line chemotherapy with Actinomycin-D and combination therapy which means complete remission of 71% with methotrexate, in comparison with 78.5% in the other group. Resistance was mostly seen in patients with documented choriocarcinoma in histology who had not received timely diagnosis and treatment. Conclusion: Individualized decision in the management of low-risk gestational trophoblastic neoplasia cases, based on histology, HCG, and history is the corn stone in successful treatment. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2008-6164 2008-6172 |
| Relation: | http://caspjim.com/article-1-3287-en.html; https://doaj.org/toc/2008-6164; https://doaj.org/toc/2008-6172 |
| Access URL: | https://doaj.org/article/041c43485ae342abad151329e092996e |
| Accession Number: | edsdoj.041c43485ae342abad151329e092996e |
| Database: | Directory of Open Access Journals |
| ISSN: | 20086164 20086172 |
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| Published in: | Caspian Journal of Internal Medicine |
| Language: | English |