Response to Rituximab after Failure of Cyclophosphamide in the Induction Treatment in a Patient with cANCA-associated Vasculitis and Pachymeningitis: a Case Report
| Title: | Response to Rituximab after Failure of Cyclophosphamide in the Induction Treatment in a Patient with cANCA-associated Vasculitis and Pachymeningitis: a Case Report |
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| Authors: | O. Psenak, R. Greil |
| Source: | Современная ревматология, Vol 15, Iss 4, Pp 68-71 (2021) |
| Publisher Information: | IMA-PRESS LLC, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine |
| Subject Terms: | canca-associated vasculitis, case report, pachymeningitis, cyclophosphamide, rituximab, Medicine |
| More Details: | A 36-year-old male patient who originally presented with recurrent inflammations in the mastoid, otitis media and peripheral facial paralysis was diagnosed with sterile pachymeningitis, associated with high titres of antineutrophil cytoplasmic antibodies (cANCA) directed against proteinase 3 (PR3). Induction therapy with oral prednisolone 1 mg/kg body weight and cyclophosphamide (CYC) 750 mg/m 2 i.v. every 4 weeks was initiated. Due to side effects, increasing arthralgias and progressive meningitis after 5 doses of CYC, treatment was changed to rituximab (RTX), one cycle comprising two administrations of 1000 mg RTX i.v. two weeks apart, repeated every 6 months. After the very first cycle of RTX, we confirmed subjective improvement of the patient’s fitness as well as radiologic response. Methotrexate (MTX) was added to ease arthralgias. Painful bleeding ulcerations on finger tips were successfully treated with 22 iloprost infusions. Up to date, we have administered 7 cycles of RTX and achieved complete remission of the cANCA-associated vasculitis. After the induction therapy, maintenance treatment with MTX or rituximab will be performed for at least 18–24 months.We can demonstrate a complete remission with the use of RTX in a patient with cANCA-associated vasculitis and sterile pachymeningitis who failed to respond to the induction treatment with CYC. RTX has been well tolerated. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Russian |
| ISSN: | 1996-7012 2310-158X |
| Relation: | https://mrj.ima-press.net/mrj/article/view/1173; https://doaj.org/toc/1996-7012; https://doaj.org/toc/2310-158X |
| DOI: | 10.14412/1996-7012-2021-4-68-71 |
| Access URL: | https://doaj.org/article/03f803d058154d89bca9b545fe5f274e |
| Accession Number: | edsdoj.03f803d058154d89bca9b545fe5f274e |
| Database: | Directory of Open Access Journals |
| ISSN: | 19967012 2310158X |
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| DOI: | 10.14412/1996-7012-2021-4-68-71 |
| Published in: | Современная ревматология |
| Language: | Russian |