Bibliographic Details
| Title: |
Metabolic reprogramming and heterogeneity during the decidualization process of endometrial stromal cells |
| Authors: |
Zhaoyu Jia, Yuan Wei, Ye Zhang, Kun Song, Jia Yuan |
| Source: |
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine
LCC:Cytology |
| Subject Terms: |
Decidualization, Lipid metabolism, Amino acid metabolism, Human endometrium, Medicine, Cytology, QH573-671 |
| More Details: |
Abstract The human endometrial decidualization is a transformative event in the pregnant uterus that involves the differentiation of stromal cells into decidual cells. While crucial to the establishment of a successful pregnancy, the metabolic characteristics of decidual cells in vivo remain largely unexplored. Here, we integrated the single-cell RNA sequencing (scRNA-seq) datasets on the endometrium of the menstrual cycle and the maternal-fetal interface in the first trimester to comprehensively decrypt the metabolic characteristics of stromal fibroblast cells. Our results revealed that the differentiation of stromal cells into decidual cells is accompanied by increased amino acid and sphingolipid metabolism. Furthermore, metabolic heterogeneity exists in decidual cells with differentiation maturity disparities. Decidual cells with high metabolism exhibit higher cellular activity and show a strong propensity for signaling. In addition, significant metabolic reprogramming in amino acids and lipids also occurs during the transition from non-pregnancy to pregnancy in the uteri of pigs, cattle, and mice. Our analysis provides comprehensive insights into the dynamic landscape of stromal fibroblast cell metabolism, contributing to our understanding of the metabolism at the molecular dynamics underlying the decidualization process in the human endometrium. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1478-811X |
| Relation: |
https://doaj.org/toc/1478-811X |
| DOI: |
10.1186/s12964-024-01763-y |
| Access URL: |
https://doaj.org/article/03e580a48cd940c3b738292af5a4b5c8 |
| Accession Number: |
edsdoj.03e580a48cd940c3b738292af5a4b5c8 |
| Database: |
Directory of Open Access Journals |
