Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Meningitis, England and Wales, July 1, 2000–June 30, 2016
| Title: | Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Meningitis, England and Wales, July 1, 2000–June 30, 2016 |
|---|---|
| Authors: | Godwin Oligbu, Sarah Collins, Abdelmajid Djennad, Carmen L. Sheppard, Norman K. Fry, Nick J. Andrews, Ray Borrow, Mary E. Ramsay, Shamez N. Ladhani |
| Source: | Emerging Infectious Diseases, Vol 25, Iss 9, Pp 1708-1718 (2019) |
| Publisher Information: | Centers for Disease Control and Prevention, 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | pneumococcal meningitis, Streptococcus pneumoniae, conjugate vaccines, epidemiology, case fatality rate, England, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | We describe the effects of the 7-valent (PCV7) and 13-valent (PCV13) pneumococcal conjugate vaccines on pneumococcal meningitis in England and Wales during July 1, 2000–June 30, 2016. Overall, 84,473 laboratory-confirmed invasive pneumococcal disease cases, including 4,160 (4.9%) cases with meningitis, occurred. PCV7 implementation in 2006 did not lower overall pneumococcal meningitis incidence because of replacement with non–PCV7-type meningitis incidence. Replacement with PCV13 in 2010, however, led to a 48% reduction in pneumococcal meningitis incidence by 2015–16. The overall case-fatality rate was 17.5%: 10.7% among patients 65 years of age. Serotype 8 was associated with increased odds of death (adjusted odds ratio 2.9, 95% CI 1.8–4.7). In England and Wales, an effect on pneumococcal meningitis was observed only after PCV13 implementation. Further studies are needed to assess pneumococcal meningitis caused by the replacing serotypes. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/25/9/18-0747_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2509.180747 |
| Access URL: | https://doaj.org/article/03d5e102f7e444539dfb1199f4f66927 |
| Accession Number: | edsdoj.03d5e102f7e444539dfb1199f4f66927 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
|---|---|
| DOI: | 10.3201/eid2509.180747 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |