Bibliographic Details
| Title: |
AURKB activates EMT through PI3K/AKT signaling axis to promote ICC progression |
| Authors: |
Peng Ma, Ying Hao, Wei Wang, Yue-Feng Zhang, Kai-Huan Yu, Wei-Xing Wang |
| Source: |
Discover Oncology, Vol 14, Iss 1, Pp 1-12 (2023) |
| Publisher Information: |
Springer, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Intrahepatic cholangiocarcinoma (ICC) is a fatal disease and the molecular mechanism of its progression remains unknown. Aurora Kinase B (AURKB) is a central regulator of chromosome separation and cytokinesis and is abnormally expressed in a variety of cancer cells. This research aimed to explore the effect of AURKB in occurrence and metastasis of ICC. We found that AURKB showed a progressive up-regulation pattern from normal bile duct tissue to ICC with high invasion. Our data showed that AURKB significantly promoted ICC cell proliferation, induced epithelial-mesenchymal transition (EMT), migration and invasion through gain- and loss- of function experiments. In vivo results consistently showed that AURKB up-regulation not only promoted tumor growth, but also promoted tumor metastasis. Importantly, we discovered that AURKB regulates the expressions of EMT-related genes via PI3K/AKT signaling axis. Herein, our results suggest that AURKB induced EMT through the activation of PI3K/AKT signaling pathway is critical to the progression of ICC, which may be a prospective therapeutic treatment for overcoming ICC metastasis and progression. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2730-6011 |
| Relation: |
https://doaj.org/toc/2730-6011 |
| DOI: |
10.1007/s12672-023-00707-1 |
| Access URL: |
https://doaj.org/article/03c69d46933a4ad08fbbb876698f7633 |
| Accession Number: |
edsdoj.03c69d46933a4ad08fbbb876698f7633 |
| Database: |
Directory of Open Access Journals |
