Academic Journal
Artemis as Predictive Biomarker of Responsiveness to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer
| Title: | Artemis as Predictive Biomarker of Responsiveness to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer |
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| Authors: | Hai Liu, Runying Huang, Jingjing Shan, Xuyun Xie, Chongwei Wang, Peng Hu, Xiaonan Sun |
| Source: | Current Oncology, Vol 31, Iss 1, Pp 535-546 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Artemis, preoperative chemoradiotherapy, radioresistance, rectal cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | The aim of this study was to identify Artemis as a predictive biomarker for guiding preoperative chemoradiotherapy in locally advanced rectal cancer. The resection specimens were collected from 50 patients with rectal cancer who underwent preoperative chemoradiotherapy. Artemis expression in biopsy tissues was evaluated using immunohistochemical staining according to the percentage of positively stained cells combined with staining intensity. Among the 50 patients, 36 (72%) had a weakly positive Artemis protein expression, 10 (20%) had a moderately positive expression, and 4 (8%) showed a strongly positive expression. The criteria of magnetic resonance imaging tumor regression grade (mrTRG) and pathological rectal cancer regression grade (RCRG) were used to assess the tumor response to chemoradiotherapy. Correlation analysis shows that there is a significant negative correlation between high Artemis immunoscore and treatment response (r = −0.532, p < 0.001). The results imply that high Artemis expression was associated with poor treatment response. Our study suggested a potential role of Artemis as a predictive biomarker of the tumor response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1718-7729 1198-0052 |
| Relation: | https://www.mdpi.com/1718-7729/31/1/37; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729 |
| DOI: | 10.3390/curroncol31010037 |
| Access URL: | https://doaj.org/article/039d42848ab64cbca45e399c682641e7 |
| Accession Number: | edsdoj.039d42848ab64cbca45e399c682641e7 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17187729 11980052 |
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| DOI: | 10.3390/curroncol31010037 |
| Published in: | Current Oncology |
| Language: | English |