Bibliographic Details
| Title: |
Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics |
| Authors: |
Volker Gerke, Felicity N. E. Gavins, Michael Geisow, Thomas Grewal, Jyoti K. Jaiswal, Jesper Nylandsted, Ursula Rescher |
| Source: |
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024) |
| Publisher Information: |
Nature Portfolio, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Abstract Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca2+-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-024-45954-0 |
| Access URL: |
https://doaj.org/article/0372b0d39f0048d4a7ebd22615898ab9 |
| Accession Number: |
edsdoj.0372b0d39f0048d4a7ebd22615898ab9 |
| Database: |
Directory of Open Access Journals |
