Academic Journal
Pectin alleviates the pulmonary inflammatory response induced by PM2.5 from a pig house by modulating intestinal microbiota
| Title: | Pectin alleviates the pulmonary inflammatory response induced by PM2.5 from a pig house by modulating intestinal microbiota |
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| Authors: | Qian Tang, Dan Shen, Pengyuan Dai, Junze Liu, Minyang Zhang, Kaidong Deng, Chunmei Li |
| Source: | Ecotoxicology and Environmental Safety, Vol 261, Iss , Pp 115099- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Environmental pollution LCC:Environmental sciences |
| Subject Terms: | PM2.5, Pectin, Lung, Intestinal microbiota, SCFA, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| More Details: | This study aimed to investigate whether dietary fiber pectin can alleviate PM2.5-induced pulmonary inflammation and the potential mechanism. PM2.5 samples were collected from a nursery pig house. The mice were divided into three groups: the control group, PM2.5 group and PM2.5 + pectin group. The mice in the PM2.5 group were intratracheally instilled with PM2.5 suspension twice a week for four consecutive weeks, and those in the PM2.5 + pectin group were subject to the same PM2.5 exposure, but fed with a basal diet supplemented with 5% pectin. The results showed that body weight and feed intake were not different among the treatments (p > 0.05). However, supplementation with pectin relieved PM2.5-induced pulmonary inflammation, presenting as slightly restored lung morphology, decreased mRNA expression levels of IL-1β, IL-6 and IL-17 in the lung, decreased MPO content in bronchoalveolar lavage fluid (BLAF), and even decreased protein levels of IL-1β and IL-6 in the serum (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651323006036; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2023.115099 |
| Access URL: | https://doaj.org/article/0287f602691241acac25da55a88c085b |
| Accession Number: | edsdoj.0287f602691241acac25da55a88c085b |
| Database: | Directory of Open Access Journals |
| ISSN: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2023.115099 |
| Published in: | Ecotoxicology and Environmental Safety |
| Language: | English |