Bibliographic Details
| Title: |
A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals |
| Authors: |
Shuji Ito, Hiroshi Takuwa, Saori Kakehi, Yuki Someya, Hideyoshi Kaga, Nobuyuki Kumahashi, Suguru Kuwata, Takuya Wakatsuki, Masaru Kadowaki, Soichiro Yamamoto, Takafumi Abe, Miwako Takeda, Yuki Ishikawa, Xiaoxi Liu, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Keiko Hikino, Kohei Tomizuka, Yukihide Momozawa, Kouichi Ozaki, Minoru Isomura, Toru Nabika, Haruka Kaneko, Muneaki Ishijima, Ryuzo Kawamori, Hirotaka Watada, Yoshifumi Tamura, Yuji Uchio, Shiro Ikegawa, Chikashi Terao |
| Source: |
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024) |
| Publisher Information: |
Nature Portfolio, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
Biology (General), QH301-705.5 |
| More Details: |
Abstract Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts. We identified a significant locus, rs10749438 which is an intronic variant in TACC2 (transforming acidic coiled-coil-containing 2) (P = 4.2 × 10−8). TACC2, encoding a cytoskeleton-related protein, is highly expressed in skeletal muscle, and is reported as a target of myotonic dystrophy 1-associated splicing alterations. These suggest that changes in TACC2 expression are associated with variations in muscle strength in older people. The association was consistently observed in young and middle-aged subjects. Our findings would shed light on genetic components of lower limb muscle strength and indicate TACC2 as a potential therapeutic target for sarcopenia. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2399-3642 |
| Relation: |
https://doaj.org/toc/2399-3642 |
| DOI: |
10.1038/s42003-024-06108-6 |
| Access URL: |
https://doaj.org/article/cd023cc995e649fbbe15c12e3ca897d0 |
| Accession Number: |
edsdoj.023cc995e649fbbe15c12e3ca897d0 |
| Database: |
Directory of Open Access Journals |
