Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits

Bibliographic Details
Title: Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits
Authors: Andrew D. Grotzinger, Javier de la Fuente, Gail Davies, Michel G. Nivard, Elliot M. Tucker-Drob
Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publisher Information: Nature Portfolio, 2022.
Publication Year: 2022
Collection: LCC:Science
Subject Terms: Science
More Details: High genetic overlap across traits requires methods that can be used to disentangle shared and unique biological pathways. Here, the authors introduce TSEM, a multivariate method for examining tissue-specific gene expression, and apply it to identify genes associated with cognitive traits.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-022-33724-9
Access URL: https://doaj.org/article/01eac78397864e54802d15cf51df6c99
Accession Number: edsdoj.01eac78397864e54802d15cf51df6c99
Database: Directory of Open Access Journals
More Details
ISSN:20411723
DOI:10.1038/s41467-022-33724-9
Published in:Nature Communications
Language:English